54394-48-8

Upstream product

• 65085-80-5 1-(4-(phenylsulfinyl)phenyl)ethanone 
• 7417-81-4 benzyl phenyl sulfoxide 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 54818-87-0 N-(4-phenylsulfanyl)phenyl acetamide 

Downstream Products

• 21229-95-8 4-(benzenesulfinyl)aniline 
• 54394-49-9 4-acetamido-3-nitrodiphenyl sulphoxide 

Relevant academic research and scientific papers

Palladium catalyzed diaryl sulfoxide generation from aryl benzyl sulfoxides and aryl chlorides

Diaryl sulfoxides are synthesized from aryl benzyl sulfoxides and aryl chlorides via three sequential catalytic cycles all promoted by a NiXantPhos-based palladium catalyst. The key step is S-arylation of a sulfenate anion. An air- and moisture-stable precatalyst derived from NiXantPhos efficiently facilitates the transformation. Various functional groups, including those with acidic protons, were tolerated. This method can also be extended to methyl and dibenzyl sulfoxides substrates.

2-Amino-4'(phenylsulfonyl) acetanilides

A method of modulating the immune response system in a warm-blooded animal by the administration of N-substituted-phenylthioanilines, N-substituted-phenylsulfinylanilines, and N-substituted-phenylsulfonylanilines, certain of which are new compounds.

Substituted (alkoxycarbonylthioureido)-(acylamino)-benzene derivatives

Benzene derivatives of the formula: STR1 wherein R1 represents alkyl, R2 represents a group --SR3, --SOR3, --SO2 R3, --OR3, --SCONH2, --SCN or --T(CH2)m T1 R4 [wherein R3 represeents alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, unsubstituted or substituted aryl, or cycloalkylalkyl, R4 represents hydrogen or alkyl, T and T1 each represent oxygen, sulphur or sulphinyl, and m is an integer from 1 to 7] whose position on the benzene ring is either para to the group --NHCSNHCOOR1 or para to the group --NHCOAZ, A represents a bivalent straight-chain aliphatic hydrocarbon radical of 1 to 4 carbon atoms or a said hydrocarbon radical substituted by at least one methyl group, and Z represents a group of the formula:- STR2 wherein R5 represents hydrogen or alkyl, R6 represents hydrogen, alkyl or phenylalkyl, and R7 represents hydrogen or alkyl, or R6 and R7 together with the nitrogen atom to which they are attached form a 5-,6- or 7-membered heterocyclic ring optionally substituted by alkyl group(s), and X- represents a pharmaceutically acceptable anion, are new compounds useful as anthelmintics and antifungal agents.