54398-51-5

Basic information

• Product Name: 6-AMINO-QUINOLINE-5-CARBONITRILE
• Synonyms: 6-AMINO-QUINOLINE-5-CARBONITRILE;6-amino-5-quinolinecarbonitrile;Quinoline-5-carbonitrile, 6-amino-
• CAS NO: 54398-51-5
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.18268
• Mol File: 54398-51-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 181 °C(Solv: chloroform (67-66-3))
• Boiling Point: 407.1°C at 760 mmHg
• Flash Point: 200°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 7.77E-07mmHg at 25°C
• Refractive Index: 1.696
• PKA: 3.79±0.15(Predicted)
• CAS DataBase Reference: 6-AMINO-QUINOLINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-QUINOLINE-5-CARBONITRILE(54398-51-5)
• EPA Substance Registry System: 6-AMINO-QUINOLINE-5-CARBONITRILE(54398-51-5)

Safety Data

• Hazardous Substances Data: 54398-51-5(Hazardous Substances Data)

Usage

General Description

6-Amino-quinoline-5-carbonitrile is a chemical compound with the molecular formula C11H8N4. It is a crystalline solid with a pale yellow color and is primarily used in the synthesis of pharmaceutical intermediates. This chemical has applications in the production of various drugs and is often used as a building block in organic synthesis. It is a versatile compound that can undergo various chemical reactions to produce a range of different products. Additionally, 6-Amino-quinoline-5-carbonitrile has potential applications in the field of medicinal chemistry and drug discovery due to its unique structural properties. Overall, this compound plays a significant role in the development and production of pharmaceuticals and other valuable chemical products.

InChI:InChI=1/C10H7N3/c11-6-8-7-2-1-5-13-10(7)4-3-9(8)12/h1-5H,12H2

Upstream product

• 108-91-8 cyclohexylamine 
• 78584-86-8 6-ethoxycarbonylaminoquinoline-5-carbonitrile 

Downstream Products

• 54398-54-8 6-phenyloxalylaminoquinoline-5-carbontrile 
• 54398-53-7 6-p-nitrobenzoylaminoquinoline-5-carbonitrile 

Relevant articles and documents

Studies on Aromatic Nitro Compounds. III. Reaction of 2-Nitronaphtalene and 6-Nitroquinoline with Malononitrile in the Presence of Amine

The reactions of 2-nitronaphthalene (I) and 6-nitroquinoline (IV) with malononitrile in the presence of an amine were examined.I reacted with malononitrile and morpholine to form 4-(1-cyano-2-naphthylcarbamoyl)morpholine (IIIa) in 43percent yield.When piperidine or pyrrolidine was used in place of morpholine, I yielded the urea derivative (IIIb or IIIc) corresponding to IIIa.From the reaction of I with cyclohexylamine, the urea derivative (IIId) and 2-cyclohexyl-1-imino-3-oxo-1,2,3,4-tetrahydrobenzoquinazoline (VIIId) were obtained in yields of 25 and 24percent, respectively.On the other hand, the reaction of I with benzylamine gave only the quinzoline derivative (VIIIe) corresponding to VIIId.Similarly, IV reacted with malononitrile and an amine to give the corresponding urea and/or quinazoline derivatives (Va-d and/or Xd, e).The structures of III, V, VIII, and X were confirmed by comparison with authentic samples prepared by an alternative route.Keywords - 2-nitronaphthalene; 6-nitroquinoline; amines; malononitrile; urea derivatives; quinazoline derivatives; 2-ethoxycarbonylaminonaphthalene-1-carbonitrile; 6-ethoxycarbonylaminoquinoline-5-carbonitrile