5440-42-6

Basic information

• Product Name: diethyl (acetylamino)(2-cyanoethyl)propanedioate
• Synonyms: Diethyl acetamido(2-cyanoethyl)malonate; propanedioic acid, 2-(acetylamino)-2-(2-cyanoethyl)-, diethyl ester
• CAS NO: 5440-42-6
• Molecular Formula: C₁₂H₁₈N₂O₅
• Molecular Weight: 270.2817
• Mol File: 5440-42-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 451.4°C at 760 mmHg
• Flash Point: 226.8°C
• Density: 1.16g/cm³
• Vapor Pressure: 2.43E-08mmHg at 25°C
• Refractive Index: 1.467
• CAS DataBase Reference: diethyl (acetylamino)(2-cyanoethyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (acetylamino)(2-cyanoethyl)propanedioate(5440-42-6)
• EPA Substance Registry System: diethyl (acetylamino)(2-cyanoethyl)propanedioate(5440-42-6)

Safety Data

• Hazardous Substances Data: 5440-42-6(Hazardous Substances Data)

Usage

General Description

Diethyl (acetylamino)(2-cyanoethyl)propanedioate, also known as ethyl 2-(acetylamino)-3-cyanoacrylate, is a chemical compound commonly used as a monomer in the production of adhesives and polymers. It is a colorless, odorless liquid that is soluble in organic solvents. diethyl (acetylamino)(2-cyanoethyl)propanedioate is often employed in medical and veterinary applications as a tissue adhesive due to its fast-curing and biocompatible properties. Additionally, it is used in the manufacturing of acrylic resins for dental fillings and as a binding agent in various industrial coatings and sealants. Diethyl (acetylamino)(2-cyanoethyl)propanedioate is considered to be relatively safe for use in these applications, but proper handling and storage procedures should be followed to minimize potential risks.

Upstream product

• 107-13-1 acrylonitrile 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 542-76-7 3-Chloropropionitrile 
• 2417-90-5 bromopropionitrile 

Downstream Products

• 70-26-8 2,5-diaminopentanoic acid 
• 617-65-2 Glutamic acid 
• 53908-65-9 4-acetamido-4,4-bis(ethyloxycarbonyl)butyraldehyde 
• 91332-08-0 F3308-3604 
• 6297-96-7 acetylamino-(3-phenylhydrazono-propyl)-malonic acid diethyl ester 
• 683200-31-9 2-Acetylamino-2-{2-[4-(4-nitro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester 
• 682737-12-8 2-Acetylamino-2-{2-[4-(3-nitro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester 
• 765243-11-6 2-Acetylamino-2-{2-[4-(4-chloro-phenyl)-thiazol-2-yl]-ethyl}-malonic acid diethyl ester 
• 777029-99-9 2-Acetylamino-2-[2-(4-phenyl-thiazol-2-yl)-ethyl]-malonic acid diethyl ester 
• 150715-97-2 2-Acetylamino-2-[2-(5-phenyl-thiazol-2-yl)-ethyl]-malonic acid diethyl ester 

Relevant articles and documents

2,5-Diamino-5,5-diphosphonovaleric Acid as a Ligand for an Osteotropic 188Re Radiopharmaceutical

A modified method for the preparation of 2,5-diamino-5,5-diphosphonovaleric acid (DADP5) has been developed in the search for new synthetically available organic ligands to produce 188Re radiopharmaceuticals with an increased accumulation in the bone tissue. Interaction of the obtained acid with 188Re was studied by radio-TLC. An optimal system for separating unbound 188Re and labeled complex in a yield of at least 95% was found. The biological distribution of 188Re-DADP5 was studied based on direct radiometric data. The osteotropicity of 188Re-DADP5 and its increased accumulation in bone fracture sites, which represent oncological pathology models, was detected at a level comparable to known radiopharmaceuticals.

Synthesis and antitrypanosomal evaluation of some thiazole-containing amino acids and peptides

Several amino acids and peptides containing thiazole and thiazolidine residues were prepared. They were tested in vivo and in vitro as possible antitrypanosomal compounds. Some derivatives showed a slight activity. As they are structurally related to glut