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CAS

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54413-32-0

1-{6-chloro-5-nitro-4-pyrimidinyl}azepane is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 54413-32-0 Structure

  • Basic information

    1. Product Name: 1-{6-chloro-5-nitro-4-pyrimidinyl}azepane
    2. Synonyms: 1-{6-chloro-5-nitro-4-pyrimidinyl}azepane
    3. CAS NO:54413-32-0
    4. Molecular Formula: C10H13ClN4O2
    5. Molecular Weight: 256.68882
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 54413-32-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-{6-chloro-5-nitro-4-pyrimidinyl}azepane(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-{6-chloro-5-nitro-4-pyrimidinyl}azepane(54413-32-0)
    11. EPA Substance Registry System: 1-{6-chloro-5-nitro-4-pyrimidinyl}azepane(54413-32-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 54413-32-0(Hazardous Substances Data)

54413-32-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 54413-32-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,4,1 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 54413-32:
(7*5)+(6*4)+(5*4)+(4*1)+(3*3)+(2*3)+(1*2)=100
100 % 10 = 0
So 54413-32-0 is a valid CAS Registry Number.

54413-32-0Relevant articles and documents

Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of Cryptococcus neoformans and Cryptococcus gattii

Donlin, Maureen J.,Lane, Thomas R.,Riabova, Olga,Lepioshkin, Alexander,Xu, Evan,Lin, Jeffrey,Makarov, Vadim,Ekins, Sean

supporting information, p. 774 - 781 (2021/05/04)

Opportunistic infections from pathogenic fungi present a major challenge to healthcare because of a very limited arsenal of antifungal drugs, an increasing population of immunosuppressed patients, and increased prevalence of resistant clinical strains due to overuse of the few available antifungals. Cryptococcal meningitis is a life-threatening opportunistic fungal infection caused by one of two species in the Cryptococcus genus, Cryptococcus neoformans and Cryptococcus gattii. Eighty percent of cryptococcosis diseases are caused by C. neoformans that is endemic in the environment. The standard of care is limited to old antifungals, and under a high standard of care, mortality remains between 10 and 30%. We have identified a series of 5-nitro-6-thiocyanatopyrimidine antifungal drug candidates using in vitro and computational machine learning approaches. These compounds can inhibit C. neoformans growth at submicromolar levels, are effective against fluconazole-resistant C. neoformans and a clinical strain of C. gattii, and are not antagonistic with currently approved antifungals.

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