5442-32-0

Basic information

• Product Name: PROPYLENE DIISOTHIURONIUM DIBROMIDE
• Synonyms: propanediisothioureadihydrobromide;PROPYLENE DIISOTHIURONIUM DIBROMIDE;2,2'-trimethylenebisisothiouronium dibromide;S,S'-(1,3-propanediyl)bis(isothiouronium bromide);2,2'-Trimethylenebis(thiouronium bromide);2,2’-trimethylene-bis-(2-thiopseudourea),dihydrobromide;2,2’-trimethylenebis(2-thio-pseudouredihydrobromide;2,2’-trimethylenedithiodi-pseudouredihydrobromide
• CAS NO: 5442-32-0
• Molecular Formula: 2BrH*C₅H₁₂N₄S₂
• Molecular Weight: 354.12946
• EINECS: 226-635-5
• Mol File: 5442-32-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 343.8°Cat760mmHg
• Flash Point: 161.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 6.86E-05mmHg at 25°C
• CAS DataBase Reference: PROPYLENE DIISOTHIURONIUM DIBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PROPYLENE DIISOTHIURONIUM DIBROMIDE(5442-32-0)
• EPA Substance Registry System: PROPYLENE DIISOTHIURONIUM DIBROMIDE(5442-32-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 5442-32-0(Hazardous Substances Data)

Usage

General Description

PROPYLENE DIISOTHIOURONIUM DIBROMIDE is a chemical compound with the molecular formula C6H12Br2N2S2. It is a white to off-white powder that is used as a biocidal agent to control microbial growth in water systems, oilfield applications, and industrial water treatment. PROPYLENE DIISOTHIURONIUM DIBROMIDE is soluble in water and has strong antimicrobial properties, making it effective in controlling the growth of bacteria, fungi, and algae. However, it is important to handle PROPYLENE DIISOTHIOURONIUM DIBROMIDE with care, as it is toxic if ingested or inhaled, and can cause skin and eye irritation. Additionally, it is harmful to aquatic life and should be disposed of properly to prevent environmental contamination.

InChI:InChI=1/C5H12N4S2.2BrH/c6-4(7)10-2-1-3-11-5(8)9;;/h1-3H2,(H3,6,7)(H3,8,9);2*1H

Upstream product

• 17356-08-0 thiourea 
• 109-64-8 1,3-dibromo-propane 
• 86768-93-6 2-(3-Bromo-propyl)-isothiourea; hydrobromide 

Downstream Products

• 115663-30-4 8,11-dioxa-1,5-dithiacyclotridecane 
• 20686-91-3 1,3-propanedisulfonyl dichloride 
• 26822-25-3 2,6,15,19-tetrathia<7,7'>paracyclophane 
• 85079-84-1 2,6-dithia<7>paracyclophane 

Relevant articles and documents

Synthesis, molecular docking studies, and biological evaluation of novel alkyl bis(4-amino-5-cyanopyrimidine) derivatives

A series of bis(4-amino-5-cyano-pyrimidines) was synthesized and evaluated as dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). To further explore the multifunctional properties of the new derivatives, their antioxidant and antibacterial activities were also tested. The results showed that most of these compounds could effectively inhibit AChE and BChE. Particularly, compound 7c exhibited the best AChE inhibitory activity (IC50 = 5.72 ± 1.53 μM), whereas compound 7h was identified as the most potent BChE inhibitor (IC50 = 12.19 ± 0.57 μM). Molecular modeling study revealed that compounds 7c, 7f, and 7b showed a higher inhibitory activity than that of galantamine against both AChE and BChE. Anticholinesterase activity of compounds 7h, 7b, and 7c was significant in vitro and in silico for both enzymes, since these compounds have hydrophobic rings (Br-phenyl, dimethyl, and methoxyphenyl), which bind very well in both sites. In addition to cholinesterase inhibitory activities, these compounds showed different levels of antioxidant activities. Indeed, in the superoxide–dimethyl sulfoxide alkaline assay, compound 7j showed very high inhibition (IC50 = 0.37 ± 0.28 μM). Also, compound 7l exhibited strong and good antibacterial activity against Staphylococcus epidermidis and Staphylococcus aureus, respectively. Taking into account the results of biological evaluation, further modifications will be designed to increase potency on different targets. In this study, the obtained results can be a new starting point for further development of multifunctional agents for the treatment of Alzheimer's disease.

The 1,4-dithiin ring opening in 1,4-dithiinodiquinolines as a route to quinoline crown thioethers

Quinoline crown thioethers (7) and (8) with 8-, 9-, 10-, 11-, 12-, 18-, 20-, 21- and 24-membered macrocyclic thiacrown ring were obtained by the 1,4- dithiin ring opening in 1,4-dithiinodiquinolines (1) and (2) with divalent sulfur nucleophiles followed by S-alkylation with divalent alkylating agents. Thiacrowns (7) and (8) contain two or four quinoline units.

ORGANIC SYNTHESIS USING PTC-5: NUCLEOPHILIC AROMATIC SUBSTITUTION UNDER LIQUID-LIQUID AND SOLID-LIQUID PHASE TRANSFER CONDITIONS.

The reaction of 1-chloro-4-nitrobenzene (1) with dithiols generated in situ from thiouronium salts (2) under PT conditions, which in turn have been procured by the reaction of appropriate α,ω-dibromoalkanes with thiourea have been investigated.The reactions of (1) with various diols have also been investigated and their reaction mechanism is discussed.