5442-90-0

Basic information

• Product Name: 2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
• Synonyms: 1H-Isoindole-1,3(2H)-dione, 2-[2-(4-morpholinyl)-2-oxoethyl]-; 2-(2-morpholino-2-oxoethyl)-1H-isoindole-1,3(2H)-dione; 2-[2-(Morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
• CAS NO: 5442-90-0
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.272
• Mol File: 5442-90-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 488.3°C at 760 mmHg
• Flash Point: 249.1°C
• Density: 1.382g/cm³
• Vapor Pressure: 1.1E-09mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione(5442-90-0)
• EPA Substance Registry System: 2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione(5442-90-0)

Safety Data

• Hazardous Substances Data: 5442-90-0(Hazardous Substances Data)

Usage

Chemical compound

2-[2-(morpholin-4-yl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Contains a morpholine ring

Heterocyclic organic compound used in pharmaceutical and chemical production

Contains an isoindole-1,3-dione ring

Important building block in organic synthesis

Potential applications in pharmaceutical industry

Possible precursor for drug synthesis

Complex structure

Requires extensive study and research to understand properties and potential uses

Upstream product

• 1440-61-5 N-chloroacetylmorpholine 
• 1074-82-4 potassium phtalimide 
• 110-91-8 morpholine 
• 39538-08-4 Phthalimidoacetic acid imidazolide 
• 6780-38-7 N-phthaloylglycine chloride 
• 4702-13-0 N-phthaloylglycine 
• 85-44-9 phthalic anhydride 

Downstream Products

• 51769-87-0 N-benzoylaminoacetic acid morpholide 
• 56414-96-1 2-amino-1-morpholinoethanone 

Relevant articles and documents

Synthesis and screening of cyclooxygenase inhibitory activity of some 1,3-dioxoisoindoline derivatives

In this study, 15 compounds bearing N,Nphthaloylacetamide structure designed by the molecular simplification approach based on thalidomide structure were synthesized and evaluated for inhibitory potencies against cyclooxgenase (COX) isoenzymes, namely COX-1 and COX-2. The results suggested that the N,Nphthaloylacetamide structure, as a primary amide, has inhibitory activity against cyclooxygenase isoenzymes with a higher COX-1 selectivity. The conversion of the primary amide to secondary or tertiary derivatives lowered the potency but favored the COX-2 selectivity thus yielding the compounds with stronger COX-2 inhibiting activity. ECV · Editio Cantor Verlag.