54420-94-9

Basic information

• Product Name: 6-Iodobenzo[d]thiazole-2-thiol
• Synonyms: 6-Iodo-2-mercaptobenzothiazole;6-Iodobenzo[d]thiazole-2-thiol;6-Iodobenzo[d]thiazole-2(3H)-thione
• CAS NO: 54420-94-9
• Molecular Formula: C7H4INS2
• Molecular Weight: 293.14783
• Mol File: 54420-94-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 6-Iodobenzo[d]thiazole-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Iodobenzo[d]thiazole-2-thiol(54420-94-9)
• EPA Substance Registry System: 6-Iodobenzo[d]thiazole-2-thiol(54420-94-9)

Safety Data

• Hazardous Substances Data: 54420-94-9(Hazardous Substances Data)

Usage

Uses

Used in Medicinal and Pharmaceutical Research:
6-Iodobenzo[d]thiazole-2-thiol serves as a key component in the development of new drugs and compounds. Its distinctive molecular structure and chemical properties contribute to its potential in drug discovery and development, making it a promising candidate for creating novel therapeutic agents.
Used in Drug Discovery and Development:
Due to its reactive thiol group and the presence of an iodine atom, 6-Iodobenzo[d]thiazole-2-thiol is utilized in the design and synthesis of pharmaceuticals. Its unique structure allows it to form new chemical entities that could address unmet medical needs or improve upon existing treatments.
Used in Chemical and Biological Fields:
Beyond its applications in medicine, 6-Iodobenzo[d]thiazole-2-thiol may also find use in other chemical and biological domains. Its reactivity and potential biological activity suggest that it could be employed in a variety of research areas, including but not limited to material science, biochemistry, and synthetic biology, where its properties could be leveraged to create new compounds or understand biological processes.

Upstream product

• 7442-07-1 6-aminobenzo[d]thiazole-2(3H)-thione 
• 29632-74-4 2-fluro-4-iodoaniline 
• 140-90-9 sodium O-ethyl dithiocarbonate 
• 337960-36-8 (6-iodo-2-benzothiazolyl)disulfide 
• 140-89-6 potassium ethyl xanthogenate 

Downstream Products

• 3748-46-7 {2-[2-chloro-4-(6-iodo-benzothiazol-2-ylsulfanylmethyl)-phenoxy]-ethyl}-diethyl-amine 
• 855282-75-6 2-chloro-6-iodobenzothiazole 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Benzothiazole-based fluorophores of donor-π-acceptor-π-donor type displaying high two-photon absorption

A series of novel heterocycle-based dyes with donor-π-bridge-acceptor- π-bridge-donor (D-π-A-π-D) structural motif, where benzothiazole serves as an electron-withdrawing core, have been designed and synthesized via palladium-catalyzed Sonogashira and Suzuki-type cross-coupling reactions. All the target chromophores show strong one-photon and two-photon excited emission. The maximum two-photon absorption (TPA) cross sections ΔTPA of the prepared derivatives bearing diphenylamino functionalities occur at wavelengths ranging from 760 to 800 nm and are as large as ～900-1100 GM. One- and two-photon absorption characteristics of the title dyes have also been investigated by using density functional theory (DFT) and the structure-property relationships are discussed. The TPA cross sections calculated by means of quadratic response time-dependent DFT using the Coulomb-attenuated CAM-B3LYP functional support the experimentally observed trends within the series, as well as higher ΔTPA values of the title compounds compared to those of analogous fluorene or carbazole-derived dyes. In contrast, the traditional B3LYP functional was not successful in predicting the observed trend of TPA cross sections for systems with different central cores. In general, structural modification of the π-bridge composition by replacement of ethynylene (alkyne) with E-ethenylene (alkene) linkages and/or replacement of dialkylamino electron-donating edge substituents by diarylamino ones results in an increase of ΔTPA values. The combination of large TPA cross sections and high emission quantum yields makes the title benzothiazole-based dyes attractive for applications involving two-photon excited fluorescence (TPEF).

BENZOTHIAZOLE AND BENZOOXAZOLE DERIVATIVES AND METHODS OF USE

Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.