5443-10-7

Usage

Chemical class

Alcohols

Common use

Protecting group for alcohols in organic synthesis

Application

Synthesis of pharmaceuticals and bioactive compounds

Unique feature

Trityl-protected hydroxyl group

Versatility

Building block in chemical synthesis

Additional uses

Production of esters and ethers

Reactivity

High

Stability

High

Safety concerns

Harmful if ingested, inhaled, or comes in contact with the skin

Safety measures

Proper handling and precautions required in laboratory or industrial settings

InChI:InChI=1/C41H36O3/c42-39(31-43-40(33-19-7-1-8-20-33,34-21-9-2-10-22-34)35-23-11-3-12-24-35)32-44-41(36-25-13-4-14-26-36,37-27-15-5-16-28-37)38-29-17-6-18-30-38/h1-30,39,42H,31-32H2

Upstream product

• 76-83-5 trityl chloride 
• 56-81-5 glycerol 
• 51621-38-6 2-stearoyloxy-1,3-bis-trityloxy-propane 

Downstream Products

• 854666-43-6 2-palmitoyloxy-1,3-bis-trityloxy-propane 
• 97488-33-0 2-lauroyloxy-1,3-bis-trityloxy-propane 
• 688319-39-3 1,3-bis(triphenylmethoxy)-2-propanone 
• 103389-86-2 2-benzoyloxy-1,3-bis-trityloxy-propane 
• 16975-62-5 tritylglycerol 
• 51621-38-6 2-stearoyloxy-1,3-bis-trityloxy-propane 
• 97924-47-5 2-methoxy-1,3-bis-trityloxy-propane 
• 96871-04-4 2-O-acetyl-1,3-di-O-tritylglycerol 
• 114838-37-8 (((2-(benzyloxy)propane-1,3-diyl)bis(oxy))bis(methanetetrayl))hexabenzene 
• 210760-40-0 3-Benzoyl-5-methyl-1-(2-trityloxy-1-trityloxymethyl-ethyl)-1H-pyrimidine-2,4-dione 
• 210760-46-6 N-[2-(2-Trityloxy-1-trityloxymethyl-ethoxy)-pyrimidin-4-yl]-benzamide 
• 596-31-6 methoxytriphenylmethane 
• 1611470-13-3 (2R,3R,4S,5S)-2-(1,3-bis(trityloxy)propan-2-yloxy)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-(4-oxopentanoyloxy)tetrahydrofuran-3-yl benzoate 
• 59237-83-1 N-1-(bistrityloxymethyl)methyluracil 

Relevant academic research and scientific papers

BORON CLUSTER-COUPLED COMPOUND

To provide a novel boron-containing compound which increases intratumorous accumulation and tumor retention, and is efficiently taken into a tumor cell.SOLUTION: The present invention relates to a compound represented by formula (I) in the figure or a salt thereof. [In the formula, X represents a divalent to pentavalent organic group; Y represents a linker structure; R represents a monovalent group comprising boron clusters; and n represents 2, 3, 4 or 5.SELECTED DRAWING: None

COMPOSITIONS AND METHODS FOR THE TREATMENT OF UREA CYCLE DISORDERS AND HEPATIC DISEASES

The compositions and compounds of formula I, formula II, formula III which includes a molecular conjugate with ornithine or its polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical composi

Total synthesis of fuzinoside

The first total syntheses of fuzinoside (1b) were achieved from d-galactose through two strategies (BCA and ABC) in 11 (total yield: 5.0%) and 15 (total yield: 3.7%) steps, respectively. Comparison of NMR data of synthetic compound 1b and those of the fuzinoside isolated from the lateral roots of Aconitum carmicaelii suggests that the structure reported in the literature1,2 might not be accurate. The synthetic fuzinoside (1b) exhibited moderate cardiac activity in the isolated bullfrog heart assay.

Synthesis and elucidation of absolute stereochemistry of salaprinol, another thiosugar sulfonium sulfate from the ayurvedic traditional medicine Salacia prinoides

Synthesis and elucidation of absolute stereochemistry of salaprinol (3) isolated from the root and stems of Salacia prinoides, which has been used for the treatment of diabetes in India, Sri Lanka, and Southeast Asia countries, is described. Compound 3 an

BIOMOLECULE LABELING REACTANTS BASED ON AZACYCLOALKANES AND CONJUGATES DERIVED THEREOF

This invention concerns novel labeling reactants based on azacycloalkanes, wherein a suitable group is linked to the molecule allowing introduction of the said molecules to bioactive molecules in solution or on solid phase.

Sterically Hindered Triacylglycerol Analogues as Potent Inhibitors of Human Digestive Lipases

A novel class of inhibitors of human digestive lipases have been developed. Various sterically hindered triacylglycerols based on 2-methyl- and 2-butylglycerol, and/or 2-methyl fatty acids were synthesized. The triacylglycerol analogues were tested for their ability to form stable monomolecular films at the air/water interface by recording their surface-pressure/molecular-area compression isotherms. The inhibition of human pancreatic and gastric lipases by the sterically hindered triacylglycerol analogues was studied by using the monolayer technique with mixed films of 1,2-dicaprin, which contained variable proportions of each inhibitor. Triolein analogues that contain a butyl group at the 2-position of the glycerol backbone or methyl groups both at the 2-position of glycerol, and the α-position of each oleic acid residue were potent inhibitors; this caused a 50% decrease in HPL activity at 0.003 molar fraction.

Synthesis of sk-membered nucleoside analogs. Part 1: Pyrimidine nucleosides based on the 1,3-dioxane ring system

The synthesis of pyrimidine nucleosides, cis-N-l-[(2-hydroxymethyl)-1,3-dioxan-5-yl]uracil (4) cfs-AM-[(2-hydroxymethyl)-1,3-dioxan-5-yl]thymine (5) and cis-Nl-[(2-hydroxymethyl)-1,3-dioxan-5-yl]cytosine (6) and their corresponding trans isomers is descri

SYNTHESIS AND CHARACTERIZATION OF 1-O-β-LACTOSYL-(R,S)-GLYCEROLS AND 1,3-DI-OΒ-LACTOSYLGLYCEROL

The synthesis of 1-O-β-lactosyl-(R,S)-glycerols was achieved by three methods: (a) in 25percent yield by the trimethylsilyl trifluoromethanesulfonate-promoted reaction of octa-O-acetyl-β-lactose (11) with ca. 0.5 mol-equiv. of 2-O-benzylglycerol (4), (b)

Lipase-Catalyzed Irreversible Transesterification for Preparative Synthesis of Chiral Glycerol Derivatives

An irreversible, lipase-catalysed transesterification using enol ester as an acylating agent has been developed for preparative enantioselective acylation of meso-1,3-diols.