54435-22-2Relevant academic research and scientific papers
NONCATALEPTIC NEUROLEPTIC AGENTS: 4-SUBSTITUTED 1-(2-CHLORO-7-FLUORO-10,11-DIHYDRODIBENZOTHIEPIN-10-YL)PIPERAZINES AND RELATED COMPOUNDS
Protiva, Miroslav,Jilek, Jiri,Cervena, Irena,Pomykacek, Josef,Bartl, Vaclav,et al.
, p. 2598 - 2616 (2007/10/02)
1-(2-chloro-7-fluoro-10,11-dihydrodibenzothiepin-10-yl)piperazine (VI) was used to prepare a new group of potential noncataleptic neuroleptic agents.Addition of acrylonitrile and acrylamide gave the nitrile VII and the amide X.Further transformations of the nitrile VII led to the phenone VIII and the amidoxime IX.Alkylations of compound VI with 2-(2-chloroethyl)-1,3-dioxolane and 2-(2-chloroethyl)-1,3-dioxane resulted in the cyclic acetals XII and XIII.Several improvements of the synthesis of compound VI are reported.Out of the compounds prepared, the amide X (methanesulfonate VUFB-15496) proved most interesting: it has low acu te toxicity, is noncataleptic and has significantly higher antidopaminergic activity than clozapine.
Dibenzo [b,f]thiepins bearing piperazinyl substitution
-
, (2008/06/13)
Compounds of the formulas SPC1 Wherein R1, R2, R3, R4, R5, R6, m and n and X are as hereinafter set forth, Are described. The compounds of formulas I and Ia are useful as neuroleptic agents
