5444-91-7

Usage

Explanation

This is the chemical name of the compound, also known as mirtazapine.

Explanation

Mirtazapine is a psychoactive substance that affects the central nervous system and has an impact on mood and emotions.

Explanation

Mirtazapine is primarily used to treat major depressive disorder by alleviating depressive symptoms.

Explanation

The molecular structure of mirtazapine consists of an indole ring system with a specific side chain attached, which contributes to its pharmacological properties.

Explanation

Mirtazapine acts as an antagonist at certain serotonin and adrenergic receptors in the brain, which helps regulate mood and emotions.

Explanation

Mirtazapine increases the levels of certain neurotransmitters, such as norepinephrine and serotonin, which play a role in mood regulation and emotional well-being.

Explanation

Apart from treating major depressive disorder, mirtazapine has also been found effective in managing anxiety, insomnia, and other mood-related disorders.

Treatment

Major depressive disorder

Chemical structure

Indole ring with a 4-methylpiperazinylmethyl side chain at the 3-position

Mechanism of action

Noradrenergic and specific serotonergic antidepressant (NaSSA)

Additional therapeutic uses

Anxiety, insomnia, and other mood disorders

InChI:InChI=1/C14H19N3/c1-16-6-8-17(9-7-16)11-12-10-15-14-5-3-2-4-13(12)14/h2-5,10,15H,6-9,11H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 771-50-6 1H-indole-3-carboxylic acid 
• 29919-22-0 1-(indole-3-carbonyl)-4-methyl-piperazine 
• 120-72-9 indole 
• 50-00-0 formaldehyd 
• 19212-84-1 1-[(4-methylpiperazin-1-yl)methyl]-1H-1,2,3-benzotriazole 

Relevant academic research and scientific papers

Synthesis and characterization of 3-substituted indole derivatives as novel mannich bases

In this study, ten 3-substituted indole derivatives at the 3rdposition of indole nucleus were synthesized via Mannich reaction with microwave assisted synthesis and the conventional reflux heating method. Microwave assisted synthesis is more pr

Bioactivity-guided synthesis of gramine derivatives as new MT1 and 5-HT1A receptors agonists

Twenty-four gramine derivatives were synthesized and evaluated on MT1 and 5-HT1A receptors in vitro. Among them, seven derivatives (7, 8, 16, 19, 20, 21, and 24) exhibited higher agonisting activities on MT1 or 5-HT1A

Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer’s Disease

Optimization of a novel series of 3-(piperazinylmethyl) indole derivatives as 5-hydroxytryptamine-6 receptor (5-HT6R) antagonists resulted in identification of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate (5al, SUVN-502) as a clinical candidate for potential treatment of cognitive disorders. It has high affinity at human 5-HT6R (Ki = 2.04 nM) and selectivity over 100 target sites which include receptors, enzymes, peptides, growth factors, ion channels, steroids, immunological factors, second messengers, and prostaglandins. It has high selectivity over 5-HT2A receptor. It is orally bioavailable and brain penetrant with robust preclinical efficacy. The combination of 5al, donepezil, and memantine (triple combination) produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus. Preclinical efficacy in triple combination and high selectivity over 5-HT2A receptors are the differentiating features which culminated in selection of 5al for further development. The Phase-1 evaluation of safety and pharmacokinetics has been completed, allowing for the initiation of a Phase-2 proof of concept study.

An efficient eco-friendly synthesis of Indole-Mannich base

An efficient and simplified protocol for three component Mannich reaction of indoles in water without using any catalyst is described. Different functionalized indole Mannich base synthesized in relatively short time with moderate to good yields. The adva

N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

The present invention relates to novel N-arylsulfonyl-3-substituted indole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their geometric forms, their N-oxides, their polymorphs, their pharmaceutically acceptable

A general synthesis of 1-(dialkylaminomethyl)indoles

1-(N,N-Dialkylamino)methylindoles are prepared from the corresponding 1-(dialkylaminomethyl)benzotriazoles by treatment with indole and base. The aminoalkylation proceeds in high yield with good regioselectivity.