544418-89-5Relevant academic research and scientific papers
Mild method for the selective esterification of carboxylic acids based on the Garegg-samuelsson reaction
Morcillo, Sara P.,Alvarez De Cienfuegos, Luis,Mota, Antonio J.,Justicia, Jose,Robles, Rafael
, p. 2277 - 2281 (2011)
A mild method for the selective esterification of primary alcohols is described. The use of different phosphines, I2, and imidazole allows the selective esterification of a wide variety of acids with excellent results. The generation of a bulky phosphonium-carboxylate salt as intermediate could justify the selectivity observed in this process. Additionally, amides also can be synthesized with use of this method.
