54447-56-2

Upstream product

• 108-24-7 acetic anhydride 
• 184000-83-7 methyl 2,3,5-tri-O-benzoyl-D-[5-13C]ribofuranoside 

Downstream Products

• 184000-88-2 2',3',5'-tri-O-benzoyl[5'-13C]ribosylthymine 
• 184000-86-0 N²-acetyl-2',3',5'-tri-O-benzoyl-6-O-diphenylcarbamoyl[5'-13C]guanosine 
• 184000-87-1 tetra-N⁴,O^2',O^3',O^5'-benzoyl[5'-13C]cytidine 
• 184000-85-9 N⁶,O^2',O^3',O^5'-tetrabenzoyl[5'-13C]adenosine 
• 240407-53-8 [5'-13C]thymidine 
• 478511-02-3 C₉⁽¹³⁾CH₁₄N₂O₆ 
• 445434-02-6 N⁴-benzoyl-2'-deoxy-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]cytidine 
• 445433-94-3 N⁴-benzoyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5-13C]cytidine 
• 445434-00-4 N⁶-benzoyl-2'-deoxy-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]adenosine 
• 445433-99-8 2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]ribosylthymine 
• 445433-92-1 C₂₈⁽¹³⁾CH₄₃N₅O₆Si₂ 
• 445433-98-7 N⁴-benzoyl-2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]cytidine 
• 445433-96-5 N⁶-benzoyl-2'-O-phenoxythiocarbonyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]adenosine 
• 445434-01-5 N²-acetyl-2'-deoxy-6-O-diphenylcarbamoyl-3',5'-O-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl[5'-13C]guanosine 

Relevant academic research and scientific papers

Synthesis of [5'-13C]ribonucleosides and 2'-deoxy[5'-13C]ribonucleosides.

The present efficient synthesis of [5'-13C]ribonucleosides and 2'-deoxy[5'-13C]ribonucleosides is characterized by the synthesis of the D-[5-13C]ribose derivative as an intermediate via the Wittig reaction of 4-aldehydo-D-erythrose dialkyl acetals with Ph3P13CH3I-BuLi to introduce the 13C label at the 5-position of a pentose. This was followed by the highly diastereoselective osmium dihydroxylation for the preparation of 2,3-di-O-benzyl-D-[5-13C]ribose dialkyl acetal and the cyclization from D-[5-13C]ribose dialkyl acetal derivatives to the alkyl D-[5-13C]ribofuranoside derivative by the use of LiBF(4). The obtained D-[5-13C]ribose derivative was converted into [5'-13C]ribonucleosides and subsequently into the corresponding 2'-deoxynucleosides.