54449-42-2

Basic information

• Product Name: 3-(3-THIENYL)-ACRYLOYL CHLORIDE
• Synonyms: 3-(3-THIENYL)-ACRYLOYL CHLORIDE;3-Thien-3-ylacryloyl chloride
• CAS NO: 54449-42-2
• Molecular Formula: C₇H₅ClOS
• Molecular Weight: 172.63
• Mol File: 54449-42-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 268.672 °C at 760 mmHg
• Flash Point: 116.289 °C
• Appearance: /
• Density: 1.345 g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 3-(3-THIENYL)-ACRYLOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-THIENYL)-ACRYLOYL CHLORIDE(54449-42-2)
• EPA Substance Registry System: 3-(3-THIENYL)-ACRYLOYL CHLORIDE(54449-42-2)

Safety Data

• Hazardous Substances Data: 54449-42-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H5ClOS/c8-7(9)2-1-6-3-4-10-5-6/h1-5H/b2-1+

Upstream product

• 1195-52-4 trans-3-(3-thienyl)acrylic acid 
• 1195-52-4 3-(3-thienyl)-2-propenoic acid 
• 498-62-4 3-thiophene carboxaldehyde 

Relevant articles and documents

Synthesis of 2-(hetero)aryl-5-(trimethylsilylethynyl)oxazoles from (hetero)arylacrylic acids

A three-step method for the synthesis of 2-(hetero)aryl-5-(trimethylsilylethynyl)oxazoles is described. Easily accessible bis(trimethylsilyl)acetylene and acrylic acid derivatives are used as starting materials for the preparation of mono- and disubstituted 5-(trimethylsilyl)pent-1-en-4-yn-3-ones. Oxidative phthalimidoaziridination of these enynones provides the key 2-acyl-1-phthalimidoaziridines that are further utilized in the thermal expansion of the three-membered ring to furnish the target functionalizable oxazoles.

The Thienopyridine and Furopyridine Rings: New Pharmacophores with Potential Antipsychotic Activity

Two new arylpiperazine derivatives, the 4-(1-piperazinyl)thieno- and -furopyridine ring systems, have been synthesized and appended via tetramethylene chains to various imide rings.Target compounds from each series were found to have significant activity in the blockade of apomorphine stereotypy and apomorphine-induced climbing, the Sidman avoidance response, and the conditioned avoidance response.In addition, while potent affinity for serotonin 5-HT1 and 5-HT2 receptors was observed for both the thieno- and furopyridine derivatives,the interaction of these molecules with the dopamine D2 receptor was weak.Electrophysiological studies of the lead prototypes from each series, involving compounds 22 and 33, indicate these two molecules have distinctively different effects on dopamine neurons in areas A9 and A10.Despite the similarity these molecules share in their behavioral indices of antipsychotic acivity, it is likely that the thieno- and furopyridine rings employ different mechanisms to achieve this convergence of biological effects.