5446-55-9Relevant academic research and scientific papers
Synthesis and evaluation of unsymmetrical heterocyclic thioureas as potent β-glucuronidase inhibitors
Taha, Muhammad,Ismail, Nor Hadiani,Jamil, Waqas,Khan, Khalid Mohammed,Salar, Uzma,Kashif, Syed Muhammad,Rahim, Fazal,Latif, Yawar
, p. 3166 - 3173 (2015/08/03)
Thiourea analogs 1-20 were synthesized and evaluated for their in vitro β-glucuronidase inhibitory potential. The compounds 9 (0.86 ± 0.01 μM), 6 (1.24 ± 0.01 μM), 16 (1.64 ± 0.02 μM) and 15 (2.12 ± 0.02 μM) showed potent activity. Other analogs 1-5, 7, 8
Pharmaceutical composition comprising N-aryl N' morpholino/piperidino thiocarbamide derivatives for treating and preventing diabetes, diabetic complications, insulin resistance and insulin resistance syndrome
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Page/Page column 3, (2008/06/13)
Disclosed is a medicament comprising N-aryl N′ morpholino/piperidino thiocarbamide derivatives represented by the following formula 1 for preventing and treating diabetes, diabetic complications, insulin resistance and insulin resistance syndrome, and can be used in drugs, foods, and beverages inducing an effect of preventing and treating diabetes, diabetic complications, insulin resistance and insulin resistance syndrome of modern people who suffer from the increasing development of diabetes resulting from environmental factors, such as intake of westernized foods, obesity, and so on: wherein, X is O or C, and R represents 4-chlorophenyl, 2-methylphenyl, 3-methoxypheny, 3-methylphenyl, or phenyl group.
Preparation and properties of antitubercular 1-piperidino-3-arylthioureas [1]
Hearn, Michael J.,Webster, Eleanor R.,Cynamon, Michael H.
, p. 1225 - 1229 (2007/10/03)
1-Piperidino-3-arylthioureas, of interest in the investigation of novel heterocyclic structures for their antitubercular activity, may be conveniently prepared in good yield and purity by the reaction of 1-aminopiperidine with aryl isothiocyanates in etha
