544676-46-2

Basic information

• Product Name: 1H-Indazole-3-carboxaldehyde, 4-[(2,3-dihydroxypropyl)thio]-6-nitro-1-phenyl-
• CAS NO: 544676-46-2
• Molecular Formula: C17H15N3O5S
• Molecular Weight: 373.389
• Mol File: 544676-46-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Indazole-3-carboxaldehyde, 4-[(2,3-dihydroxypropyl)thio]-6-nitro-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole-3-carboxaldehyde, 4-[(2,3-dihydroxypropyl)thio]-6-nitro-1-phenyl-(544676-46-2)
• EPA Substance Registry System: 1H-Indazole-3-carboxaldehyde, 4-[(2,3-dihydroxypropyl)thio]-6-nitro-1-phenyl-(544676-46-2)

Safety Data

• Hazardous Substances Data: 544676-46-2(Hazardous Substances Data)

Upstream product

• 96-27-5 rac-3-sulfanylpropane-1,2-diol 
• 544676-41-7 3-formyl-4,6-dinitro-1-phenyl-1H-indazole 
• 62-53-3 aniline 
• 544676-42-8 (4,6-dinitro-1-phenyl-1H-indazol-3-yl)(ethoxy)methanol 

Relevant articles and documents

Synthesis of 3-substituted 1-aryl-4,6-dinitro-1H-indazoles based on picrylacetaldehyde and their behavior in nucleophilic substitution reactions

A method for the synthesis of 1-aryl-3-formyl-4,6-dinitro-1H-indazoles by the reaction of picrylacetaldehyde with aryldiazonium salts followed by intramolecular cyclization of the resulting picrylglyoxal monoarylhydrazones was developed. Various 4,6-dinitro-1-phenyl-1H-indazoles substituted in position 3 were prepared via transformations involving the formyl group of 3-formyl-4,6-dinitro-1-phenyl-1H-indazole. 3-R-4,6-Dinitro-1-phenyl-1H- indazoles (R = CHO, CN, 1,3-dioxolan-2-yl) react regiospecifically with anionic O-, S-, and N-nucleophiles, in particular, with replacement of only the 4-NO2 group. Thus previously unknown 3-R-4-Nu-6-nitro-1-phenyl-1H- indazoles were synthesized (Nu is a nucleophile residue).