544707-19-9 Usage
Description
JNJ 10181457 dihydrochloride is a selective non-imidazole histamine H3 receptor antagonist that plays a crucial role in normalizing acetylcholine neurotransmission. It is a compound with significant potential in the pharmaceutical industry due to its ability to modulate histamine H3 receptor activity, which can have various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
JNJ 10181457 dihydrochloride is used as a histamine H3 receptor antagonist for normalizing acetylcholine neurotransmission. This application is particularly relevant in the treatment of various neurological and cognitive disorders, as well as in enhancing wakefulness and attention.
Used in Neurological Applications:
JNJ 10181457 dihydrochloride is used as a therapeutic agent for treating neurological disorders characterized by imbalances in acetylcholine neurotransmission. By acting as a histamine H3 receptor antagonist, it can help alleviate symptoms and improve the overall quality of life for patients suffering from such conditions.
Used in Cognitive Enhancement:
JNJ 10181457 dihydrochloride is used as a cognitive enhancer to improve wakefulness and attention. Its ability to modulate histamine H3 receptor activity can lead to increased alertness and cognitive performance, making it a promising candidate for the development of medications aimed at treating conditions related to cognitive impairment or fatigue.
Used in Sleep-Wake Regulation:
JNJ 10181457 dihydrochloride is used as a regulator of the sleep-wake cycle. By inhibiting the histamine H3 receptor, it can help maintain a balance between sleep and wakefulness, potentially benefiting individuals with sleep disorders or those who require enhanced alertness for professional or personal reasons.
Check Digit Verification of cas no
The CAS Registry Mumber 544707-19-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,4,4,7,0 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 544707-19:
(8*5)+(7*4)+(6*4)+(5*7)+(4*0)+(3*7)+(2*1)+(1*9)=159
159 % 10 = 9
So 544707-19-9 is a valid CAS Registry Number.
544707-19-9Relevant articles and documents
Diamine-based human histamine H3 receptor antagonists: (4-Aminobutyn-1-yl)benzylamines
Dvorak, Curt A.,Apodaca, Richard,Xiao, Wei,Jablonowski, Jill A.,Bonaventure, Pascal,Dugovic, Christine,Shelton, Jonathan,Lord, Brian,Miller, Kirsten,Dvorak, Lisa K.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
experimental part, p. 4098 - 4106 (2009/12/06)
A series of (4-aminobutyn-1-yl)benzylamines were prepared and the SAR around three key areas: (1) the amine attached to the butynyl linker (R3R4N-); (2) the benzylamine moiety (R1R2N-); and (3) the point of attachment of the benzylamine group (R1R2N- in the ortho, meta, or para positions) was examined. One compound, 4-[3-(4-piperidin-1-yl-but-1-ynyl)-benzyl]-morpholine (9s) was chosen for further profiling and found to be a selective histamine H3 antagonist with desirable drug-like properties. Ex vivo receptor occupancy studies established that 9s does occupy H3 binding sites in the brain of rats after oral administration. Subcutaneous doses of 9s (10 mg/kg) given during the natural sleep phase demonstrated robust wake-promoting effects.
Phenylalkynes
-
, (2008/06/13)
Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
