5448-17-9Relevant academic research and scientific papers
Gold-catalyzed formation of pyrrolo- and indolo-oxazin-1-one derivatives: The key structure of some marine natural products
Taskaya, Sultan,Menges, Nurettin,Balci, Metin
supporting information, p. 897 - 905 (2015/08/18)
Various N-propargylpyrrole and indolecarboxylic acids were efficiently converted into 3,4-dihydropyrrolo- and indolo-oxazin-1-one derivatives by a gold(III)-catalyzed cyclization reaction. Some of the products underwent TFA-catalyzed double bond isomerization and some did not. Cyclization reactions in the presence of alcohol catalyzed by Au(I) resulted in the formation of hemiacetals after cascade reactions.
Process for the preparation of 2,4-dimethyl-3,5-bisalkoxycarbonylpyrrole
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, (2008/06/13)
A process for the preparation of 2,4-dimethyl-3,5-bisalkoxycarbonylpyrrole is described, in which an acetoacetic alkyl ester is nitrosated to give the 2-nitrosoacetoacetic alkyl ester, the nitroso compound is reduced using hydrogen in the presence of a noble metal catalyst to give the amine, and the resulting amino compound is condensed without isolation in the presence of the corresponding non-nitrosated acetoacetic alkyl ester to give the 2,4-dimethyl-3,5-bisalkoxycarbonylpyrrole. The process makes it possible to work under conditions which are milder than in the prior art and to avoid the formation of by-products.
