5449-68-3

Basic information

• Product Name: (1-hydroxycyclohexyl)(phenyl)acetic acid
• CAS NO: 5449-68-3
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.2909
• Mol File: 5449-68-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 398°C at 760 mmHg
• Flash Point: 208.7°C
• Density: 1.219g/cm³
• Vapor Pressure: 4.76E-07mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: (1-hydroxycyclohexyl)(phenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1-hydroxycyclohexyl)(phenyl)acetic acid(5449-68-3)
• EPA Substance Registry System: (1-hydroxycyclohexyl)(phenyl)acetic acid(5449-68-3)

Safety Data

• Hazardous Substances Data: 5449-68-3(Hazardous Substances Data)

Usage

General Description

(1-hydroxycyclohexyl)(phenyl)acetic acid, also known as HPCA, is a chemical compound with a molecular formula C18H20O3. It is a carboxylic acid derivative, and its structure consists of a cyclohexyl ring and a phenyl group linked to a carboxylic acid. HPCA is used in the synthesis of pharmaceuticals and is also a key ingredient in the production of perfumes and fragrances due to its pleasant aroma. Additionally, it has been studied for its potential anti-inflammatory and analgesic properties. However, further research is needed to fully understand its pharmacological potential. Overall, HPCA is a versatile chemical with various industrial and potential medicinal applications.

Upstream product

• 103-82-2 phenylacetic acid 
• 108-94-1 cyclohexanone 
• 95777-19-8 phenylacetic acid magnesium enediolate 
• 15082-44-7 dilithium phenyl acetic acid 
• 79801-99-3 1-(1-phenylpropen-2-yl)cyclohexane-1-ol 
• 920-39-8 isopropylmagnesium bromide 
• 114-70-5 sodium phenylacetate 
• 1068-55-9 isopropylmagnesium chloride 

Downstream Products

• 93005-50-6 cyclohexylidene-phenyl-acetic acid 
• 55930-32-0 N-Hydroxy-2-(1-hydroxy-cyclohexyl)-2-phenyl-acetamide 
• 1456505-14-8 (R+S) 4-(2-oxo-4-phenyl-1-oxa-3-azaspiro[4.5]decan-3-yl)-N-(quinolin-8-yl)benzamide 
• 16112-49-5 5,5-Pentamethylen-4-phenyloxazolidin-2-on 
• 121813-74-9 diethyl-{2-[(1-hydroxy-cyclohexyl)-phenyl-acetoxy]-ethyl}-phenacyl-ammonium; bromide 
• 119572-13-3 diethyl-benzyl-{2-[(1-hydroxy-cyclohexyl)-phenyl-acetoxy]-ethyl}-ammonium; bromide 
• 114493-08-2 diethyl-allyl-{2-[(1-hydroxy-cyclohexyl)-phenyl-acetoxy]-ethyl}-ammonium; bromide 
• 3894-09-5 2-cyclohexyl-2-phenylacetic acid 
• 51535-51-4 2-(1-cyclohexenyl)-2-phenylacetic acid 
• 7465-32-9 3-phenyl-1-oxaspiro[3.5]nonan-2-one 
• 102371-04-0 BL₅₀₂₈₁ 
• 103-82-2 phenylacetic acid 
• 108-94-1 cyclohexanone 

Relevant articles and documents

OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF

Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

AN EFFICIENT, HIGHLY REGIOSELECTIVE SYNTHESIS OF SUBSTITUTED (1-CYCLOHEXENYL) ACETIC ACID DERIVATIVES VIA IONIZATION/ELIMINATION OF β-LACTONES

When treated with magnesium bromide, spiro β-lactones undergo an ionization/elimination reaction to afford cyclohexenyl acetic acid derivatives in high yield and isomeric purity.

STRUCTURE DU REACTIF D'IVANOV ET DE QUELQUES ORGANOMETALLIQUES ISSUS DES DERIVES PHENYLACETIQUES-II. STEREOCHEMIE DE LA CONDENSATION AVEC LA t-BUTYL-4 CYCLOHEXANONE

Ivanov reagent and some other analogous reagents (phenyl acetique serie) have been condensed with t-Bu-4 cyclohexanone in order to complete investigation of the reactive species.In all the cases, equatorial attack is highly predominant; it let suppose tha