5449-68-3

Usage

Uses

Used in Pharmaceutical Synthesis:
HPCA is utilized as an intermediate in the synthesis of various pharmaceuticals, playing a crucial role in the development of new medications due to its chemical properties.
Used in Perfumery and Fragrance Production:
HPCA serves as a key ingredient in the production of perfumes and fragrances, valued for its pleasant aroma that enhances the sensory experience of these products.
Used in Anti-inflammatory and Analgesic Research:
HPCA has been studied for its potential anti-inflammatory and analgesic properties, indicating its possible use in the development of treatments for pain and inflammation. However, further research is necessary to fully explore and understand its pharmacological potential.
Used in Chemical Research:
As a versatile chemical compound, HPCA is also used in chemical research for understanding its properties and exploring its potential applications in various industries.

Upstream product

• 1068-55-9 isopropylmagnesium chloride 
• 114-70-5 sodium phenylacetate 
• 920-39-8 isopropylmagnesium bromide 
• 103-82-2 phenylacetic acid 
• 108-94-1 cyclohexanone 
• 95777-19-8 phenylacetic acid magnesium enediolate 
• 15082-44-7 dilithium phenyl acetic acid 
• 79801-99-3 1-(1-phenylpropen-2-yl)cyclohexane-1-ol 

Downstream Products

• 103-82-2 phenylacetic acid 
• 108-94-1 cyclohexanone 
• 93005-50-6 cyclohexylidene-phenyl-acetic acid 
• 55930-32-0 N-Hydroxy-2-(1-hydroxy-cyclohexyl)-2-phenyl-acetamide 
• 7465-32-9 3-phenyl-1-oxaspiro[3.5]nonan-2-one 
• 16112-49-5 5,5-Pentamethylen-4-phenyloxazolidin-2-on 
• 1456505-14-8 (R+S) 4-(2-oxo-4-phenyl-1-oxa-3-azaspiro[4.5]decan-3-yl)-N-(quinolin-8-yl)benzamide 
• 121813-74-9 diethyl-{2-[(1-hydroxy-cyclohexyl)-phenyl-acetoxy]-ethyl}-phenacyl-ammonium; bromide 
• 119572-13-3 diethyl-benzyl-{2-[(1-hydroxy-cyclohexyl)-phenyl-acetoxy]-ethyl}-ammonium; bromide 
• 114493-08-2 diethyl-allyl-{2-[(1-hydroxy-cyclohexyl)-phenyl-acetoxy]-ethyl}-ammonium; bromide 
• 3894-09-5 2-cyclohexyl-2-phenylacetic acid 
• 51535-51-4 2-(1-cyclohexenyl)-2-phenylacetic acid 
• 102371-04-0 BL₅₀₂₈₁ 

Relevant academic research and scientific papers

OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF

Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

SYNTHETIS OF CYCLIC AND ACYCLIC β,γ-UNSATURATED CARBOXYLIC ACIDS VIA AN E1-TYPE IONIZATION/ELIMINATION OF β-LACTONES

Cyclic and acyclic ketones were converted in three steps into 3-alkenoic acids, bearing a variety of substituents in the α-position.The sequence, involving ionization/elimination of a β-lactone, affords high yields of pure products uncontaminated with conjugated isomers.Support for an E1-type mechanism is also provided.

AN EFFICIENT, HIGHLY REGIOSELECTIVE SYNTHESIS OF SUBSTITUTED (1-CYCLOHEXENYL) ACETIC ACID DERIVATIVES VIA IONIZATION/ELIMINATION OF β-LACTONES

When treated with magnesium bromide, spiro β-lactones undergo an ionization/elimination reaction to afford cyclohexenyl acetic acid derivatives in high yield and isomeric purity.

Kinetics and Mechanism of the Ivanov Reaction: Reaction of Aldehydes and Ketones with Phenylacetic Acit Magnesium Enediolate

Stopped-flow kinetics of the reaction between aldehydes or ketones and the magnesium enediolate of phenylacetic acid in THF are second order at enediolate concentrations -3 M.At concentrations of 10-3 - 3*10-2 M, the formation of a bis(enediolate) requires a more complex kinetic equation.Second-order rate constans are reported for the reaction of the enediolate with a number of aldehydes and ketones at 25 deg C.Entropies of activation for cyclohexanone, benzaldehyde, 2-methylpropanal, and 2,2-dimethylpropanal are positive, and enthalpy-entropy compensation is observed.Ef fects of cycloalkanone ring size and benzaldehyde substituents are small and are ascribable to a transition state with a very small C-C bond order.A two-step mechanism is proposed, with preequilibrium formation of a coordination intermediate which, in some cases, is accompanied by a change in the magnesium coordination number.Effects of alkyl groups on aldehyde and ketone reactivity stem mainly from steric desolvation.

STRUCTURE DU REACTIF D'IVANOV ET DE QUELQUES ORGANOMETALLIQUES ISSUS DES DERIVES PHENYLACETIQUES-II. STEREOCHEMIE DE LA CONDENSATION AVEC LA t-BUTYL-4 CYCLOHEXANONE

Ivanov reagent and some other analogous reagents (phenyl acetique serie) have been condensed with t-Bu-4 cyclohexanone in order to complete investigation of the reactive species.In all the cases, equatorial attack is highly predominant; it let suppose tha