545-90-4Relevant articles and documents
Process for the preparation of optically active methadones in high enantiomeric purity
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, (2008/06/13)
PCT No. PCT/GB97/01441 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed May 27, 1997 PCT Pub. No. WO97/45551 PCT Pub. Date Dec. 4, 1997A method of preparing optically active methadones comprises an enzymatic process for the resolution of 1-dialkyl-amino-2-propanol and conversion of the enantiomers to the optically active methadones in high enantiomeric purity.
Synthesis of a new metabolite of acetylmethadol
Booher,Pohland
, p. 266 - 268 (2007/10/06)
The primary amine metabolites of α (±) and α (-) acetylmethadol were synthesized. A neutral permanganate oxidation of noracetylmethadol gave a nitroalkane. This unusual oxidation product was readily converted to the primary amine metabolite of acetylmetha