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Alphamethadol, also known as α-Methadol or LAAM, is a synthetic opioid medication primarily used to treat opioid dependence. It is a long-acting alternative to methadone, with a similar mechanism of action, binding to opioid receptors in the brain to reduce withdrawal symptoms and cravings. Alphamethadol is typically administered in a once-every-three-days dosing schedule, providing a more convenient treatment option for patients. However, it is important to note that Alphamethadol has been associated with serious cardiac side effects, such as QT interval prolongation and torsades de pointes, which can lead to life-threatening arrhythmias. Due to these risks, its use has been restricted or discontinued in several countries, and it is not as widely prescribed as methadone for opioid addiction treatment.

545-90-4

545-90-4 Suppliers

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545-90-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 545-90-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 545-90:
(5*5)+(4*4)+(3*5)+(2*9)+(1*0)=74
74 % 10 = 4
So 545-90-4 is a valid CAS Registry Number.
InChI:InChI=1/C21H29NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17,20,23H,5,16H2,1-4H3

545-90-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Alphamethadol

1.2 Other means of identification

Product number -
Other names 6-Dimethylamino-4,4-diphenyl-3-heptanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:545-90-4 SDS

545-90-4Relevant academic research and scientific papers

Process for the preparation of optically active methadones in high enantiomeric purity

-

, (2008/06/13)

PCT No. PCT/GB97/01441 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed May 27, 1997 PCT Pub. No. WO97/45551 PCT Pub. Date Dec. 4, 1997A method of preparing optically active methadones comprises an enzymatic process for the resolution of 1-dialkyl-amino-2-propanol and conversion of the enantiomers to the optically active methadones in high enantiomeric purity.

GLYCOCONJUGATES OF OPIATED SUBSTANCES

-

, (2008/06/13)

They are comprised of a series of derivatives of carbohydrates of a family of biologically active opiated agents, which present in their structure at least one residue of carbohydrate per opiate molecule, linked directly to a hydroxyl group of the opiate or through a C-glycoside bond formed between two functions situated at each of the two constitutive parts of the glycoconjugate. Said derivatives contain more than one carbohydrate residue and/or more than one opiate molecule per carbohydrate residue. The acid salts and the compounds of said opiated glycoconjugates are also included in the disclosed compounds of said invention.

Synthesis of a new metabolite of acetylmethadol

Booher,Pohland

, p. 266 - 268 (2007/10/06)

The primary amine metabolites of α (±) and α (-) acetylmethadol were synthesized. A neutral permanganate oxidation of noracetylmethadol gave a nitroalkane. This unusual oxidation product was readily converted to the primary amine metabolite of acetylmetha