54501-54-1Relevant academic research and scientific papers
Oxidative peptide bond formation of glycine-amino acid using 2-(aminomethyl)malononitrile as a glycine unit
Wang, Xiaoling,Li, Jing,Hayashi, Yujiro
supporting information, p. 4283 - 4286 (2021/05/05)
Amide linkage of glycine-amino acid was synthesized by coupling of substituted 2-(aminomethyl)malononitrile as a C-terminal glycine unit and N-terminal amine using CsOAc and O2in an aqueous solution. This is a coupling reagent-free and catalyst-free peptide synthesisviaoxidative amide bond formation. Various tripeptides and tetrapeptides were synthesized efficiently and the sulfide moiety is inert even under an oxygen atmosphere.
11C-Labelling of Substance P. Preparation of a Homocysteine-containing Precursor and its Subsequent Application in the Synthesis of the Labelled Neuropeptide
Franzen, Henry M.,Ragnarsson, Ulf,Nagren, Kjell,Langstroem, Bengt
, p. 2241 - 2248 (2007/10/02)
The synthesis of a useful 11>Substance P derivative (16), containing only two protecting groups both labile to sodium in liquid ammonia, by a multistep strategy in solution, is reported.This approach furnished solid intermediates
A CONVENIENT METHOD FOR THE SYNTHESIS OF CARBOXAMIDES AND PEPTIDES BY THE USE OF TETRABUTYLAMMONIUM SALTS
Watanabe, Yutaka,Mukaiyama, Teruaki
, p. 285 - 288 (2007/10/02)
Various carboxamides and peptides are prepared in good yields by treatment of free acids and amines in H2O-dichloromethane or aqueous THF with bis(o-nitrophenyl) phenylphosphonate in the presence of tetrabutylammonium hydrogen sulfate or bromide.Carboxylic esters are also successfully converted to amides via carboxylate salts in one-pot.
