5451-55-8

Usage

Uses

Used in Pharmaceutical Industry:
4-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID is used as a reactant for the preparation of N-((S)-3-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)-1-henylpropyl)-4-tert-butylcyclohexanecarboxamide, which is a compound with potential pharmaceutical applications.
Used in Enzyme Inhibition:
In the field of biochemistry and drug development, 4-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID is used as a reactant in the synthesis of cycloalkylamide derivatives. These derivatives serve as inhibitors of soluble epoxide hydrolase, an enzyme that plays a role in various biological processes and diseases. By inhibiting this enzyme, the cycloalkylamide derivatives may have therapeutic potential in treating conditions related to the dysregulation of soluble epoxide hydrolase.

InChI:InChI=1/C11H20O2/c1-11(2,3)9-6-4-8(5-7-9)10(12)13/h8-9H,4-7H2,1-3H3,(H,12,13)

Upstream product

• 201230-82-2 carbon monoxide 
• 2228-98-0 4-tert-butylcylohexene 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 

Downstream Products

• 907-04-0 bis-(trans-4-tert-butyl-cyclohexanecarbonyl)-peroxide 
• 907-04-0 bis-(cis-4-tert-butyl-cyclohexanecarbonyl)-peroxide 
• 20451-50-7 cis-4-tert-butylcyclohexylcarbonyl chloride 
• 17177-75-2 methyl ester of trans-4-tert-butylcyclohexanecarboxylic acid 
• 17177-76-3 methyl esters of cis-4-tert-butylcyclohexanecarboxylic acid 
• 19091-08-8 methyl 4-tert-butyl-cyclohexanecarboxylate 
• 63767-85-1 ethyl 4-tert-butylcyclohexane-1-carboxylate 
• 28112-56-3 trans-(4-tert-Butylcyclohexyl)phenylketon 
• 18525-42-3 cis-(4-tert-Butylcyclohexyl)phenylketon 
• 169822-48-4 4-tert-Butyl-1-(9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-cyclohexanecarboxylic acid 
• 5400-88-4 4-tert-butylcyclohexylamine 
• 741291-95-2 C₁₉H₂₇NO₄ 

Relevant academic research and scientific papers

Study on the enolization of alkyl of cis and trans 2-tert-5-X-1,3-dioxanes (X =CO2CH3, CHO, COPh, NO2, and CN). Evidence for stereoelectronic control.

Alkylation ot 2-tert-butyl-5-X-1,3-dioxanes (X = CO2CH3,COPh and NO2) was studied.Products resulting from an equatorial approach of the alkylating agent are preferentially formed when X = CO2CH3 and NO2.Also, the cis isomers that have an equatorial hydrog

The Stereochemistry of Organometallic Compounds. XXII The Stereochemistry of Metal-Catalysed Hydrogen Cyanide Addition to Olefins

Reactions of (E)-3,3-dimethyl(1,2-D2)but-1-ene with hydrogen cyanide and of (E)-3,3-dimethyl(1-D)but-1-ene with deuterium cyanide have been shown to proceed in a completely stereospecific cis fashion when a catalyst system based on Pd(diop)2 was used.Reaction between 4-t-butylcyclohexene and deuterium cyanide with the catalyst system gave only the equatorial nitriles trans-4-t-butylcyclohexane-1-carbonitrile and cis-3-t-butylcyclohexane-1-carbonitrile with cis incorporation of deuterium.Use of a catalyst system based on Ni4 and zinc chloride led to significant amounts of isotopic exchange and rearrangement.These results are compared with those from hydroformylation of the olefins, and the mechanism of hydrocyanation is discussed

Stereochemistry of Decarbalkoxylation of Cyclic Geminal Diesters Effected by Water and Lithium Chloride in Me2SO

The stereochemical consequences of the decarbalkoxylation of cyclic geminal diesters by LiCl-H2O-Me2SO have been examined.The norbornene diester 13 and the norbornane diester 16 lead predominantly to the exoesters 14 and 17, respectively.The 2-methylcyclohexane diester 22 leads to esters containing more cis (23) than trans (24) isomer.The diesters 19,25, and 28 lead to nearly equal amounts of the cis and trans esters.In these latter cases,the enolates generated from the esters (via LDA) are protonated in a nonstereoselective fashion on quenching with water.This is suggestive of an enolate intermediate in the decarbalkoxylation reaction.The implications of these sterochemical results are discussed.