54521-26-5

Basic information

• Product Name: 1-(2,6-dimethylbenzyl)piperidine
• Synonyms: 1-(2,6-dimethylbenzyl)piperidine
• CAS NO: 54521-26-5
• Molecular Weight: 203.327
• Mol File: 54521-26-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2,6-dimethylbenzyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-dimethylbenzyl)piperidine(54521-26-5)
• EPA Substance Registry System: 1-(2,6-dimethylbenzyl)piperidine(54521-26-5)

Safety Data

• Hazardous Substances Data: 54521-26-5(Hazardous Substances Data)

Upstream product

• 1158827-76-9 Br^(1-)*C₁₄H₂₂N⁽¹⁺⁾ 
• 6781-98-2 2,6-dimethyl-1-chlorobenzene 
• 1268340-93-7 N-(trifluoroboratomethyl)piperidine internal salt 
• 110-89-4 piperidine 
• 58924-23-5 2,6-dimethylphenyl methanesulfonate 

Relevant articles and documents

Reinvestigation of aminomethyltrifluoroborates and their application in suzuki-miyaura cross-coupling reactions

A reinvestigation into the chemical composition of potassium aminomethyltrifluoroborates is reported. These trifluoroborato salts have been reassigned as zwitterionic ammoniomethyltrifluoroborates. Minor adjustments to the previously disclosed reaction conditions are reported that permit a similar level of activity as nucleophiles in Suzuki-Miyaura cross-coupling reactions.

Scope of aminomethylations via Suzuki-Miyaura cross-coupling of orsanotrifluoroborates

(Chemical Equation Presented) We previously reported the Suzuki-Miyaura reaction of N,N-dialkylaminomethyltrifluoroborates with aryl bromides. Herein, we report a further investigation of the scope and limitations of this palladium-catalyzed aminomethylation reaction. Aryl chlorides, iodides, and triflates coupled in good to excellent yields to give N,N-dialkylbenzylic amines. The aminomethylation of alkenyl bromides was also examined.