545339-02-4

Basic information

• Product Name: 1-Propanone, 2,2-difluoro-1-(4-methoxyphenyl)-3-phenyl-3-(phenylamino)-
• CAS NO: 545339-02-4
• Molecular Formula: C22H19F2NO2
• Molecular Weight: 367.395
• Mol File: 545339-02-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2,2-difluoro-1-(4-methoxyphenyl)-3-phenyl-3-(phenylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2,2-difluoro-1-(4-methoxyphenyl)-3-phenyl-3-(phenylamino)-(545339-02-4)
• EPA Substance Registry System: 1-Propanone, 2,2-difluoro-1-(4-methoxyphenyl)-3-phenyl-3-(phenylamino)-(545339-02-4)

Safety Data

• Hazardous Substances Data: 545339-02-4(Hazardous Substances Data)

Upstream product

• 538-51-2 benzylidene phenylamine 

Downstream Products

• 545338-98-5 2,2-difluoro-1-(4-methoxyphenyl)-3-[N-phenyl-N-(trifluoroacetyl)amino]-3-phenylpropan-1-one 

Relevant articles and documents

A new finding in selective Baeyer-Villiger oxidation of α-fluorinated ketones; a new and practical route for the synthesis of α-fluorinated esters

α-Fluorinated esters were effectively prepared by the Baeyer-Villiger oxidation of α-fluorinated ketones with m-chloroperbenzoic acid (m-CPBA) under mild conditions. The yield of the esters was influenced by the choice of solvent, base, and substituent on the aryl group of the ketones. 4-Methoxyphenyl substituted fluoroketones were oxidized almost quantitatively with m-CPBA within 10 min to 12 h at room temperature using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a cosolvent with CH2Cl2 (1:1, v/v) and aqueous buffer (KH2PO4-NaOH, pH 7.6) as an additive base. The oxidation reaction rates of α-fluorinated ketones were higher than those of the corresponding non-fluorinated ketones. The fluorine atom at α-position of fluoromethyl aryl ketones enhanced the reactivity in the Baeyer-Villiger oxidation.