54534-92-8Relevant academic research and scientific papers
NRF2 REGULATORS
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Page/Page column 123, (2017/01/02)
Provided are aryl analogs,pharmaceutical compositions containing them and their use as NRF2 regulators.
LRRK2 INHIBITORS
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Page/Page column 121-122, (2013/02/28)
Provided herein are compounds that inhibit or partially inhibit the activity of leucine rich repeat kinases. Also provided herein are methods of treatment of CNS disorders comprising administration of inhibitors of leucine rich repeat kinases.
Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Young, Robert J.,Borthwick, Alan D.,Brown, David,Burns-Kurtis, Cynthia L.,Campbell, Matthew,Chan, Chuen,Charbaut, Marie,Convery, Maire A.,Diallo, Hawa,Hortense, Eric,Irving, Wendy R.,Kelly, Henry A.,King, N. Paul,Kleanthous, Savvas,Mason, Andrew M.,Pateman, Anthony J.,Patikis, Angela N.,Pinto, Ivan L.,Pollard, Derek R.,Senger, Stefan,Shah, Gita P.,Toomey, John R.,Watson, Nigel S.,Weston, Helen E.,Zhou, Ping
, p. 28 - 33 (2008/09/17)
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activities and encouraging oral pharmacokinetic profiles.
