54537-74-5

Basic information

• Product Name: 5-(3,4-Dimethoxy-phenyl)-2-methanesulfinyl-3-oxo-pentanoic acid phenylamide
• CAS NO: 54537-74-5
• Molecular Weight: 389.472
• Mol File: 54537-74-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3,4-Dimethoxy-phenyl)-2-methanesulfinyl-3-oxo-pentanoic acid phenylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-Dimethoxy-phenyl)-2-methanesulfinyl-3-oxo-pentanoic acid phenylamide(54537-74-5)
• EPA Substance Registry System: 5-(3,4-Dimethoxy-phenyl)-2-methanesulfinyl-3-oxo-pentanoic acid phenylamide(54537-74-5)

Safety Data

• Hazardous Substances Data: 54537-74-5(Hazardous Substances Data)

Upstream product

• 33212-96-3 3,4-Dimethoxyphenethyl-methyl-sulfinyl-methyl-keton 
• 103-71-9 phenyl isocyanate 
• 5462-13-5 ethyl 3-(3,4-dimethoxyphenyl)propionate 

Downstream Products

• 54537-77-8 2-Hydroxy-6,7-dimethoxy-naphthalene-1-carboxylic acid phenylamide 

Relevant articles and documents

Cyclization of β-ketosulfoxide-III. Synthesis of naphthalene and phenanthrene derivatives

On heating with trichloroacetic acid or trifluoroacetic acid, 2,4-dimethoxyphenethyl methylsulfinylmethyl ketone (1) cyclized to 2,3-dimethoxy-5-methylthio-6-oxo-5, 6, 7, 8-tetrahydronaphthalene (2) through an intramolecular nucleophilic substitution of a sulfonium ion intermediate (20b), while a β -ketosulfoxide having naphthalene nucleus (3) cyclized to a tetrahydrophenanthrene 4 via a Pummerer rearrangement product 23. Treatment of 1 with p-toluenesulfonic acid gave a mixture of 2,3,6-trisubstituted naphthalenes (7-10), whose composition was dependent on the reaction conditions. The aromatization proceeded via 2.