54540-53-3

Usage

Structure

A derivative of benzene with a bromine atom attached to the third carbon, a propyl group attached to the first carbon, and a methyl group attached to the fourth carbon.

Usage

Commonly used in organic synthesis and as a building block for the production of other chemicals.

Applications

Utilized in the production of pharmaceuticals, fragrances, and flavorings.

Physical state

Flammable liquid.

Odor

Strong, unpleasant odor.

Safety precautions

Should be handled and stored with care in a well-ventilated area.

Upstream product

• 3333-13-9 p-allyltoluene 
• 5406-39-3 3-(4-methylphenyl)propanol 
• 106-38-7 para-bromotoluene 
• 109-64-8 1,3-dibromo-propane 
• 1505-50-6 3-(4-Methylphenyl)propanoic acid 
• 1866-39-3 trans-p-methylcinnamic acid 
• 56955-36-3 methyl 3-(p-tolyl)propionate 
• 1866-39-3 4-methylcinnamic acid 

Downstream Products

• 54540-54-4 2-(3,5-Dimethoxyphenyl)-5-(4-Methylphenyl)Pentane 
• 132352-74-0 O-(3-(4-methylphenyl)-1-propyl) benzohydroxamate 
• 112298-28-9 5-(p-methylphenyl)-1,1,1-trifluoropentan-2-one 
• 116748-65-3 2-(3-p-Tolyl-propoxy)-benzaldehyde 
• 86373-48-0 4-(3-p-Tolyl-propylamino)-benzoic acid 
• 1093172-44-1 [2,2-dimethyl-5-(2-{4-[3-(4-methylphenyl)propoxy]-3-trifluoromethylphenyl}ethyl)-1,3-dioxan-5-yl]carbamic acid t-butyl ester 
• 112023-32-2 bis-(4-p-tolyl-butyryl)-amine 
• 132352-84-2 N-chloro-O-(3-(4-methylphenyl)-1-propyl) benzohydroxamate 
• 116748-48-2 (5Z,10Z,14Z,19Z)-2,3,7,8,12,13,17,18-Octamethyl-5,15-bis-[2-(3-p-tolyl-propoxy)-phenyl]-porphyrin 
• 116748-31-3 2,3,7,8,12,13,17,18-Octamethyl-5,15-bis-[2-(3-p-tolyl-propoxy)-phenyl]-porphyrinogene 
• 112298-09-6 5-(p-methylphenyl)-1,1,1-trifluoropentan-2-ol triflate 
• 112319-75-2 5-(p-methylphenyl)-2-phenyl-1,1,1-trifluoropentan-2-ol 
• 112298-34-7 7-methyl-1-phenyl-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalene 
• 112298-13-2 5-(p-methylphenyl)-1,1,1-trifluoropentan-2-ol 

Relevant academic research and scientific papers

B(C6F5)3-Catalyzed Diastereoselective Formal (4 + 1)-Cycloaddition of Vinylcyclopropanes and Et2SiH2

A formal (4 + 1)-cycloaddition of vinylcyclopropanes and Et2SiH2 to afford 3,4-disubstituted silolanes is reported. The reaction sequence commences with the known B(C6F5)3-catalyzed alkene hydrosilylation with dihydrosilanes. Cleavage of the remaining Si-H bond in the hydrosilylation product assisted by B(C6F5)3 leads to formation of a cyclopropane-stabilized silylium ion. The activated cyclopropane ring is then opened by the in situ-generated borohydride accompanied by ring closure to the silolane. The diastereoselectivity is rationalized by a mechanistic model.

Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity

The treatment for patients with chronic obstructive pulmonary disease (COPD) usually involves a combination of anti-inflammatory and bronchodilatory drugs. We recently found that mepenzolate bromide (1) and its derivative, 3-(2-hydroxy-2, 2-diphenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (5), have both anti-inflammatory and bronchodilatory activities. We chemically modified 5 with a view to obtain derivatives with both anti-inflammatory and longer-lasting bronchodilatory activities. Among the synthesized compounds, (R)-(–)-12 ((R)-3-(2-hydroxy-2,2-diphenylacetoxy)-1-(3-phenylpropyl)-1-azoniabicyclo[2.2.2]octane bromide) showed the highest affinity in vitro for the human muscarinic M3 receptor (hM3R). Compared to 1 and 5, (R)-(–)-12 exhibited longer-lasting bronchodilatory activity and equivalent anti-inflammatory effect in mice. The long-term intratracheal administration of (R)-(–)-12 suppressed porcine pancreatic elastase-induced pulmonary emphysema in mice, whereas the same procedure with a long-acting muscarinic antagonist used clinically (tiotropium bromide) did not. These results suggest that (R)-(–)-12 might be therapeutically beneficial for use with COPD patients given the improved effects seen against both inflammatory pulmonary emphysema and airflow limitation in this animal model.

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

Saturated heterocyclic carboxamide derivatives

A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. STR1

ALKOXYNITRENIUM ION CYCLISATIONS: EVIDENCE FOR DIFFERENT MECHANISMS IN THE FORMATION OF BENZOXAZINES AND BENZOXAZEPINES.

Deuterium labelling experiments and n.m.r. studies indicate that cyclisations of N-acyl-N-(2-phenylethyloxy)nitrenium ions occur via direct attack at the ortho position to give 3,4-dihydro-1H-2,1-benzoxazines.In contrast N-acyl-N-(3-phenylpropyloxy)nitrenium ions cyclise to 1,3,4,5-tetrahydro-2,1-benzoxazepines through ipso attack followed by 1,2-carbon migration.In both cases hydrogen circumambulation occurs in the sigma complex before aromatisation.

Drugs derived from cannabinoids. 5. Δ(6a,10a) Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains

Ten new Δ(6a,10a) THC analogs with arylalkyl side chains, one with a dimethylaminoalkyl side chain, and six heterocyclic Δ(6a,10a) THC analogs [8 substituted 5,5 dimethyl 10 hydroxy 2 (2 propynyl) 1,2,3,4 tetrahydro 5H [1] benzo pyranol [4,3 c] pyridines] were prepared. They showed pharmacological activity as analgesics, tranquilizers, antihypertensives, and hypnotics and as antisecretory, antiulcer, and antidiarrheal agents. The most potent compounds had either a 1 methyl 4 (4 fluorophenyl) butyl or a 1,2 dimethyl 4 (4 fluorophenyl) butyl side chain.