54543-01-0Relevant academic research and scientific papers
An expeditious synthesis of (±)-desepoxy-4,5-didehydromethylenomycin A methyl ester
Balczewski, Piotr,Mikolajczyk, Marian
, p. 1153 - 1154 (2007/10/03)
A total synthesis of the racemic methyl ester of desepoxy-4,5-didehydromethylenomycin A has been achieved in six steps with an overall yield of 31% starting from diethyl methanephosphonate. The key steps include the Nazarov cyclization of the dienone 7 leading to the α-phosphoryl cyclopentenone 8 and the Horner-Wittig reaction of the latter employed for the introduction of the exocyclic methylene moiety.
