545445-75-8

Upstream product

• 545445-76-9 (3R,5S)-3,5-Dimethyl-6-oxo-hexanoic acid methyl ester 
• 545445-77-0 (2S,4R)-5-azido-2,4-dimethylpentyl phenyl sulfone 
• 157733-59-0 [2R,4S]-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester 
• 82917-26-8 [2R,4S]-5-hydroxy-2,4-dimethyl-pentanoic acid methyl ester 
• 143291-59-2 [2R,4S]-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentan-1-ol 
• 545445-82-7 (2S,4R)-5-azido-2,4-dimethylpentan-1-ol 4-methylbenzenesulfonate 
• 545445-80-5 (2R,4S)-1-azido-5-{[(tert-butyl)dimethylsilyl]oxy}-2,4-dimethylpentane 
• 545445-79-2 (3R,5S)-6-{[(tert-butyl)dimethylsilyl]oxy}-3,5-dimethylhexanenitrile 
• 545445-78-1 (2R,4S)-5-{[(tert-butyl)dimethylsilyl]oxy}-1-iodo-2,4-dimethylpentane 
• 545445-74-7 methyl (3R,5S)-6-hydroxy-3,5-dimethylhexanoate 
• 545445-81-6 (2S,4R)-5-azido-2,4-dimethylpentan-1-ol 
• 82917-27-9 [2S,4R]-2,4-dimethyl-pentanedioic acid monomethyl ester 

Downstream Products

• 545445-83-8 methyl (3R,5S,6RS,7RS,8S,10R)-6-(acetyloxy)-11-azido-3,5,8,10-tetramethyl-7-(phenylsulfonyl)undecanoate 

Relevant academic research and scientific papers

Synthesis of a conformationally flexible β-hairpin mimetic

Rational conformation design led us to a synthesis of the ω-amido-undecenamide 4, which was shown by theoretical means (simulated annealing techniques) and by NMR and IR spectroscopy to have a high tendency to populate a conformation corresponding to a natural β-II′-type hairpin, despite possessing a conformationally fully flexible open-chain backbone.