54549-19-8

Basic information

• Product Name: beta-cis-2-(4-Chlorobenzhydryl)-3-quinuclidinol
• Synonyms: beta-cis-2-(4-Chlorobenzhydryl)-3-quinuclidinol;[2alpha(R*),3alpha]-2-[(4-Chlorophenyl)phenylmethyl]-1-azabicyclo[2.2.2]octan-3-ol
• CAS NO: 54549-19-8
• Molecular Formula: C₂₀H₂₂ClNO
• Molecular Weight: 327.8478
• Mol File: 54549-19-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 463.2°Cat760mmHg
• Flash Point: 233.9°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 2.24E-09mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: beta-cis-2-(4-Chlorobenzhydryl)-3-quinuclidinol(CAS DataBase Reference)
• NIST Chemistry Reference: beta-cis-2-(4-Chlorobenzhydryl)-3-quinuclidinol(54549-19-8)
• EPA Substance Registry System: beta-cis-2-(4-Chlorobenzhydryl)-3-quinuclidinol(54549-19-8)

Safety Data

• Hazardous Substances Data: 54549-19-8(Hazardous Substances Data)

Usage

Description

Beta-cis-2-(4-Chlorobenzhydryl)-3-quinuclidinol, commonly known as Cisapride, is a medication primarily used to treat gastrointestinal motility disorders such as gastroesophageal reflux disease (GERD) and gastroparesis. It functions by enhancing muscle contractions in the upper digestive tract, thereby facilitating the efficient movement of food through the stomach and intestines. As a benzhydryl compound, Cisapride exhibits antihistaminic and antiemetic properties. However, its use is restricted in some countries due to the potential risk of causing serious cardiac arrhythmias. It is crucial to use this medication under the guidance of a healthcare professional and to be cognizant of its potential risks and side effects.

Uses

Used in Gastrointestinal Disorders Treatment:
Cisapride is utilized as a prokinetic agent for the treatment of gastrointestinal motility disorders, such as gastroesophageal reflux disease (GERD) and gastroparesis. It increases the muscle contractions in the upper digestive tract, promoting the efficient movement of food through the stomach and intestines.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Cisapride is used as an active pharmaceutical ingredient in medications designed to improve gastrointestinal motility. Its antihistaminic and antiemetic properties also contribute to its therapeutic effects in treating various gastrointestinal conditions.

InChI:InChI=1/C20H22ClNO/c21-17-8-6-15(7-9-17)18(14-4-2-1-3-5-14)19-20(23)16-10-12-22(19)13-11-16/h1-9,16,18-20,23H,10-13H2/t18?,19-,20+/m0/s1