5455-00-5Relevant academic research and scientific papers
Synthesis of mono-, bis-spiro- and dispiro-β-lactams and evaluation of their antimalarial activities
Jarrahpour, Aliasghar,Ebrahimi, Edris,De Clercq, Erik,Sinou, Véronique,Latour, Christine,Djouhri Bouktab, Lamia,Brunel, Jean Michel
experimental part, p. 8699 - 8704 (2011/12/02)
Some new mono-, bis-spiro- and dispiro-β-lactams have been synthesized from imines derived from 9H-fluoren-9-one and a ketene derived from 9H-xanthene-9-carboxylic acid or phenoxyacetic acid by a [2+2] cycloaddition reaction in good to excellent yields va
Intramolecular Addition of Aryl Radicals to Carbon-Nitrogen Double Bonds
Gioanola, Milena,Leardini, Rino,Nanni, Daniele,Pareschi, Patrizia,Zanardi, Giuseppe
, p. 2039 - 2054 (2007/10/02)
Cyclisation of radicals 6a,b is highly regioselective towards a 5-exo process; 6-endo ring closure is a minor route and their ratio depends on the substituents.No ring expansion of the five-membered radical intermediates 7a,b was observed.Radicals 27a,b give rise to 5-exo cyclisation regiospecifically.A competitive 1,5-hydrogen shift leading to imidoyl radicals was noticed.An analogous behaviour is also exhibited by vinyl radicals when allowed to add to carbon-nitrogen double bonds.
