54553-22-9

Upstream product

• 146064-45-1 diethyl (α-thiocyanatomethyl)phosphonate 
• 135-02-4 ortho-anisaldehyde 
• 578-57-4 2-bromoanisole 
• 682-30-4 Diethyl vinylphosphonate 
• 15241-32-4 1-methoxy-2-(2-nitrovinyl)benzene 
• 762-04-9 phosphonic acid diethyl ester 
• 3316-24-3 1-methoxy-2-((E)-2-nitrovinyl)benzene 
• 1660-94-2 Tetraethyl methylenediphosphonate 

Relevant academic research and scientific papers

Reaction of diethyl thiocyanatomethylphosphonate with aldehydes as a route to diethyl Z-1-alkenylphosphonates

Diastereoselective synthesis of diethyl Z-1-alkenylphosphonates from easily available diethyl thiocyanatomethylphosphonate and aromatic aldehydes has been developed. Olefination of the aldehydes occurs under mild conditions and affords the title compounds with moderate yields. A plausible mechanism of the above-mentioned reaction is also discussed.

A (E) - 2-aryl ethylene cinnamenyl method for preparing ester derivative

The invention discloses method for preparing (E)-2-aryl vinyl phosphonate derivatives. The method comprises the specific following steps of dissolving 1-nitro-2-aryl-vinyl derivatives, a phosphorus reagent, an accelerator manganese acetate and a catalyst copper acetate in a solvent and reacting at 20-100 DEG C to obtain the (E)-2-aryl vinyl phosphonate derivatives. According to the method disclosed by the invention, the 1-nitro-2-aryl-vinyl derivatives are adopted as starting materials, the raw materials are easily available and have multiple varieties; the products obtained by the method disclosed by the invention are multiple and can be directly applied and can be also used for other further reaction; according to the method, the use of precious metal reagents and other additives is avoided; and meanwhile, the synthetic route is short, reaction conditions are mild, the reaction operation and post-treatment process are simple, the yield is high and the method is suitable for scale production.

Manganese(iii)-mediated alkenyl Csp2-P bond formation from the reaction of β-nitrostyrenes with dialkyl phosphites

Mn(OAc)3-mediated tandem phosphonyl radical addition to β-nitrostyrenes followed by denitration to form (E)-2-alkenyl phosphonates in good yield is described.

Synthesis of diethyl 2-(aryl)vinylphosphonates by the Heck reaction catalysed by well-defined palladium complexes

Pd-catalysed procedures for the direct Heck arylation of diethyl vinylphosphonate with various aryl or heteroaryl halides toward the synthesis of diethyl 2-(aryl)vinylphosphonates are reported. Several homogeneous catalytic systems (i.e. Herrmann palladacycle, Nolan (NHC)-palladium catalyst, Pd(OAc)2/PPh3) were used and compared within the study. High conversions and selectivities were achieved under optimised conditions (2 mol% [Pd], NMP, K2CO3, 140 °C) whatever the homogeneous catalyst used.

Regio- and stereoselective synthesis of 2-amino-1-hydroxy-2-aryl ethylphosphonic esters

A highly regio- and diastereoselective synthesis of 2-amino-1-hydroxy-2-aryl ethylphosphonic esters was achieved by opening trans 1,2-epoxy-2-aryl ethylphosphonic esters with 28% NH(3(aq.)) in methanol. (C) 2000 Published by Elsevier Science Ltd.