54558-30-4Relevant academic research and scientific papers
Targeting DNA with small molecules: A comparative study of a library of azonia aromatic chromophores
Surez, Rosa M.,Bosch, Pedro,Sucunza, David,Cuadro, Ana M.,Domingo, Alberto,Mendicuti, Francisco,Vaquero, Juan J.
, p. 527 - 538 (2015/02/19)
A library of azonia aromatic cations has been studied in order to gain insights into the effect of the size, shape and charge distribution on the fluorescence, DNA interactions and DNA sequence selectivity properties. Fluorescence-based thermal denaturation experiments, spectrofluorimetric titrations, circular dichroism measurements and theoretical simulations have shown that some of the studied chromophores have interesting fluorescence properties and two of them also show a consistent DNA-binding ability by intercalation, with a potential preference for AT-rich sequences.
Method for treating fibrotic diseases or other indications with imidazolium agents
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, (2008/06/13)
Provided is a method of treating or ameliorating an indication of the invention in an animal, including a human, by administering an effective amount of a compound of the formula I: wherein R1, R2, M, X and Z are as described supra. Also provided are certain imidazolium compounds and pharmaceutical compositions containing the imidazolium compounds.
Method for treating fibrotic diseases or other indications IC
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, (2011/07/06)
Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:
Westphal Condensation of N-Aminocycloiminium Salts. Synthesis of Fused Pyridazinium Derivatives
Matia, Maria P.,Garcia-Navio, Jose L.,Vaquero, Juan J.,Alvarez-Builla, Julio
, p. 777 - 780 (2007/10/02)
A series of α-alkyl-N-aminoazinium and -azolium salts 1-15 have been condensed with 1,2-dicarbonyl compounds to produce new heterocyclic cationic species 17-25 with a quaternary nitrogen atom in the bridgehead position.Key Words: Westphal condensation / N
