5456-89-3

Usage

Uses

Used in Organic Synthesis:
[(E)-(4-methylphenyl)diazenyl]propanedinitrile is used as a reagent in organic synthesis for the formation of carbon-carbon bonds. Its unique diazo group allows for versatile reactions, making it a valuable component in creating complex organic molecules.
Used as a Dye or Pigment:
Due to its striking yellow to orange color, [(E)-(4-methylphenyl)diazenyl]propanedinitrile is utilized as a dye or pigment in the production of various materials. Its color intensity and stability make it suitable for a range of applications, from textiles to paints and coatings.
Used in Antimicrobial Applications:
[(E)-(4-methylphenyl)diazenyl]propanedinitrile has been studied for its potential antimicrobial properties. Preliminary research indicates that it may have activity against certain types of bacteria, making it a candidate for further development as an antimicrobial agent.
Used in Anticancer Research:
[(E)-(4-methylphenyl)diazenyl]propanedinitrile has also shown promise in anticancer activities during initial studies. Its potential to target and affect cancer cells is currently being explored, with the aim of developing it into a more effective treatment option for various types of cancer.

Upstream product

• 2028-84-4 p-methylbenzenediazonium chloride 
• 109-77-3 malononitrile 
• 106-49-0 p-toluidine 

Downstream Products

• 94051-89-5 2-Cyano-N-hydroxy-2-p-tolylazo-acetamidine 
• 3656-03-9 3,5-diamino-4-(p-tolylazo)pyrazole 
• 114299-66-0 3-(3,5-Diamino-4-p-tolylazo-pyrazol-1-yl)-propionitrile 
• 94051-90-8 4-p-Tolylazo-isoxazole-3,5-diamine 
• 114275-65-9 5,7-Dimethyl-3-p-tolylazo-pyrazolo[1,5-a]pyrimidin-2-ylamine 
• 114275-68-2 2-Amino-5-methyl-3-p-tolylazo-pyrazolo[1,5-a]pyrimidin-7-ol 
• 114275-45-5 2-Amino-3-p-tolylazo-6,7-dihydro-4H-pyrazolo[1,5-a]pyrimidin-5-one 
• 114275-60-4 2,7-Diamino-3-p-tolylazo-pyrazolo[1,5-a]pyrimidine-6-carbonitrile 
• 114299-68-2 2-Amino-7-oxo-3-p-tolylazo-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-6-carbonitrile 
• 114299-69-3 4,7-Diamino-8-p-tolylazo-pyrazolo[5,1-c][1,2,4]triazine-3-carbonitrile 
• 114275-48-8 7-Amino-9-p-tolylazo-1,3,4,5-tetrahydro-1,4a,4b,8-tetraaza-fluoren-2-one 
• 114275-76-2 7-Amino-4-methyl-8-p-tolylazo-pyrazolo[5,1-c][1,2,4]triazine-3-carboxylic acid ethyl ester 
• 114275-73-9 7-Amino-4-phenyl-8-p-tolylazo-pyrazolo[5,1-c][1,2,4]triazine-3-carbonitrile 
• 114299-70-6 1,3-Diphenyl-7-p-tolylazo-1H-pyrazolo[5,1-c][1,2,4]triazol-6-ylamine 

Relevant academic research and scientific papers

Synthesis and Pharmacological Investigations of Novel Pyrazolyl and Hydrazonoyl Cyanide Benzimidazole Entities

Various novel benzimidazole entities linked to pyrazolyl and hydrazonoyl cyanide substrates carrying aryl and heteroaryl groups (8a–e to 10a–e) were synthesized using new route syntheses and were focused on their pharmacological evaluation as one of the m

Total chemical synthesis method of adenine

The invention relates to a total chemical synthesis method of adenine. The method comprises the following steps of: 1) dissolving primary amine in strong-acid solution, dripping sodium nitrite solution to prepare diazonium salt, adding malononitrile for dissolving, and dripping alkaline solution to regulate a pH value of reaction solution and generate coupling reaction, thereby obtaining an azo compound; 2) adding the azo compound into formamide, and introducing liquid ammonia, heating to carry out high-temperature condensation and cyclization reaction, thereby obtaining a pyrimidine-azo compound; 3) dissolving the pyrimidine-azo compound into water, adding a catalyst, and introducing hydrogen for hydrogenation, thereby obtaining 4,5,6-triamidopyrimidine; and 4) dissolving the 4, 5, 6-triamidopyrimidine into the formamide to carry out high-temperature cyclization with the formamide, thereby obtaining an adenine crude product, and after recrystallization, obtaining white crystalline powder, i.e., a high-purity refined adenine product. The total chemical synthesis method has the advantages that water is used as a solvent in the step 1), and solvents used in the steps 2), 3) and 4) can be repeatedly used, so that the 'three wastes' are fewer, and the environment-friendly effect is achieved; and the total yield is 64.75% (calculated according to the amount of malononitrile), and the cost is low, so that the industrialization is easy and the economic benefit is obvious.

Adenine intermediate pyrimidine-azo compound and preparation method thereof

The invention relates to an adenine intermediate pyrimidine-azo compound and a preparation method thereof. The preparation method comprises the following steps of: 1) dissolving primary amine in mixed-acid solution, dripping sodium nitrite solution to prepare diazonium salt shown in a formula (3), adding malononitrile for dissolving, and dripping alkaline solution to regulate a pH value of reaction solution and generate coupling reaction, thereby obtaining an intermediate pyrimidine-azo compound (4); 2) adding the intermediate pyrimidine-azo compound (4) prepared in the step 1) into formamide, introducing liquid ammonia, and heating to carry out high-temperature condensation and cyclization reaction, thereby obtaining an adenine intermediate pyrimidine-azo compound (5), wherein a series of derivatives of the adenine intermediate pyrimidine-azo compound can be prepared by selecting different primary amines. The adenine intermediate pyrimidine-azo compound and the preparation method have the advantages that water is used as a solvent in the step 1), and the solvent used in the step 2) can be repeatedly used, so that the 'three wastes' are fewer, and the environment-friendly effect is achieved; and the cost is low, so that the industrialization is easy and the economic benefit is obvious.

DFT, FT-IR, FT-Raman and NMR studies of 4-(substituted phenylazo)-3,5- diacetamido-1H-pyrazoles

We present a detailed analysis of the structural and vibrational spectra of some novel azo dyes. 2-(Substituted phenylazo)malononitriles were synthesized by the coupling reaction of the diazonium salts, which were prepared with the use of various aniline

Synthesis and characterization of Ni(II) and Cd(II) complexes of 4-(4-nitrophenylazo)- 1H-pyrazole-3,5-diamine and 4-(4-methylphenylazo)-1H- pyrazole-3,5-diamine

In this study, the diazotized p-nitroaniline and p-methylaniline were coupled with malononitrile. The ring closure reaction of the obtained products with hydrazine monohydrate yielded 4-(4-methylphenylazo)-1H-pyrazole-3,5-diamine (L1) and 4-(4-nitrophenylazo)-1H-pyrazole- 3,5-diamine (L 2). The structure of the ligands has been elucidated by spectroscopic analyses. Then, novel Ni(II) and Cd(II) complexes of the ligands have been synthesized and the structures of these complexes determined by elemental analysis, spectrometric and TGA/DTA methods, molar conductance and magnetic susceptibility measurements. All the complexes were monomeric and diamagnetic. From the elemental analyses and mass spectra data, the complexes were proposed to the formulae [Ni2(L1)2(OH) 2]·2Cl·8.5H2O, [Cd2(L 1)2(OH)2]·2Cl·DMF·3H2O, [Ni(L2)2]·2Cl·2DMF·7H2O and [Cd2(L2)2(OH)2(H 2O)4]·2Cl·1.5H2O. For the Cd(L2) complex octahedral geometry was proposed, but the Ni(L 1), Ni(L2) and Cd(L1) complexes show four coordinated structure. The Ni(L1), Cd(L1) and Cd(L 2) complexes were found to be dinuclear. On the other hand the Ni(L2) complex was found to be mononuclear. All the complexes were found to be (1:2) electrolytes.

Pyridazine derivatives and related compounds. 23*. synthesis of 3-substituted pyrazolo[3,4-c] pyridazines and their application as disperse dyes

Acetylacetone and malononitrile were coupled with diazotized arylamines to give arylazoacetylacetones and arylazomalononitriles. When refluxed with 3-hydrazino-4,5-diphenyl-1H-pyrazolo-[3,4-c]pyridazine in the presence of ethanol/HCl, they yielded the corresponding 3-[4-(arylazo)-3,5-dimethylpyrazol- 1-yl]- and 3-[3,5-diamino-4-(arylazo)pyrazol-1-yl]-4,5-diphenyl-1H-pyrazolo[3,4- c]pyridazine dyes. The dyes were applied to polyester and polyamide fabrics, and their spectral and fastness properties were measured.