54568-56-8Relevant academic research and scientific papers
Synthesis of 4-substituted- and 1,4-disubstituted-4-hydroxypyrrolidin-2- ones
Kinsinger, Christopher R.,Tatko, Chad D.,Whelan, Christopher M.,Wilkinson, Timothy J.
, p. 1845 - 1852 (2008/02/02)
This report describes the synthesis of 4-substituted- and 1,4-disubstituted-4-hydroxypyrrolidin-2-ones by cyclization of intermediate γ-aminoesters prepared from alkylbenzylamines, α-bromoketones, and lithio ethyl acetate. Copyright Taylor & Francis Group, LLC.
Photochemical Reaction of α-Alkyl-β-oxoamides. Competitive γ- and δ-Hydrogen Abstraction by Excited Ketone Carbonyl Groups
Hasegawa, Tadashi,Arata, Yoshiaki,Mizuno, Kouichi,Masuda, Kenji,Yoshihara, Nobutoshi
, p. 541 - 544 (2007/10/02)
The α-alkyl-β-oxoamides (1a-i) undergo the Norrish Type II photoreaction.The excited ketone carbonyl group in the β-oxoamides (1c, 1f-i) abstracts γ- and δ-hydrogen competitively from the n,?* triplet state.The regioselectivity of the hydrogen abstraction is affected by both the γ- and the δ-substituents.The presence of γ- or δ-substitution increases the γ- or the δ-hydrogen abstraction, respectively.The δ-hydrogen abstraction greatly predominates over the γ-hydrogen absraction in the photolyses of the α-ethyl-β-oxoamides (1f) and (1i).
