54573-21-6

Upstream product

• 6315-89-5 3,4-dimethoxyaniline 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 173043-92-0 3,4-dimethoxy-N-methyl-N-trifluoroacetylaniline 
• 173043-93-1 3,4-dihydroxy-N-methyl-N-trifluoroacetylaniline 
• 173043-82-8 3,4-bis<(tert-butyldimethylsilyl)oxy>-N-methylaniline 
• 173043-83-9 3,4-bis<(tert-butyldimethylsilyl)oxy>-N-methyl-N-nitrosoaniline 
• 173043-81-7 3,4-bis<(tert-butyldimethylsilyl)oxy>-N-methyl-N-trifluoroacetylaniline 

Relevant academic research and scientific papers

Reagent- and Metal-Free Anodic C?C Cross-Coupling of Aniline Derivatives

The dehydrogenative cross-coupling of aniline derivatives to 2,2′-diaminobiaryls is reported. The oxidation is carried out electrochemically, which avoids the use of metals and reagents. A large variety of biphenyldiamines were thus prepared. The best results were obtained when glassy carbon was used as the anode material. The electrosynthetic reaction is easily performed in an undivided cell at slightly elevated temperature. In addition, common amine protecting groups based on carboxylic acids were employed that can be selectively removed under mild conditions after the cross-coupling, which provides quick and efficient access to important building blocks featuring free amine moieties.

Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs

We have synthesized derivatives of dephostatin, a protein tyrosine phosphatase (PTPase) inhibitor, to study the structure-activity relationships of this inhibitor. Inactive analogs revealed some insight into structural requirements for PTPase inhibitory activity of dephostatin. Both a nitroso group and phenolic hydroxyl groups were found to be essential for the inhibitory activity. Among the dephostatin derivatives synthesized, one of the regioisomers of dephostatin showed PTPase inhibitory activity equivalent to that of dephostatin, and also had increased stability.