5458-26-4

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-propan-2-ylphenyl)-1,3-dioxolane is used as a neuroleptic and anxiolytic agent for the treatment of psychiatric disorders such as schizophrenia and anxiety. Its mechanism of action involves the modulation of neurotransmitter levels, specifically dopamine and serotonin, which helps in alleviating symptoms of psychosis and anxiety.
The use of tiapride is typically oral, with a relatively fast onset of action, making it a suitable option for managing acute symptoms. However, patients are advised to follow medical guidance on dosage and usage to minimize the risk of side effects, which may include drowsiness, dizziness, and gastrointestinal disturbances.

InChI:InChI=1/C12H16O2/c1-9(2)10-3-5-11(6-4-10)12-13-7-8-14-12/h3-6,9,12H,7-8H2,1-2H3

Upstream product

• 107-21-1 ethylene glycol 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 13816-33-6 p-Cyanocumen 

Relevant academic research and scientific papers

Inhibition by Water during Heterogeneous Br?nsted Acid Catalysis by Three-Dimensional Crystalline Organic Salts

A new self-assembled and self-healing class of metal free, recyclable, heterogeneous Br?nsted acid catalysts has been developed by the protonation of aniline derivatives (tetrakis(4-aminophenyl)methane, leuco-crystal violet, benzidine, and p-phenylenediamine) with aromatic sulfonic acids (tetrakis(phenyl-4-sulfonic acid)methane, and 2,6-naphthalenedisulfonic acid). As a result, five three-dimensional crystalline organic salts (F-1a, F-1b, F-1c, F-2, and F-3) were obtained, linked by hydrogen bonds and additionally stabilized by the opposite charges of the components. Frameworks F-2 and F-3 were prepared for the first time and characterized by elemental analysis, X-ray structural analysis (for F-2), thermogravimetry, SEM, and FTIR spectroscopy. The catalytic activities of crystalline organic salts F-1-3 have been explored in industrially important epoxide ring-opening and acetal formation reactions. The presence of encapsulated water inside frameworks F-1a and F-2 had an inhibitory effect on the performance of the catalysts. X-ray diffraction analysis of hydrated and dehydrated samples of F-1a and F-2 indicated that water of crystallization served as a cross-linking agent, diminishing the substrate induced "breathing"affinities of the frameworks.

Application of poly(Vinylbenzyltrimethylammonium tribromide) resin as an efficient polymeric catalyst in the acetalization and diacetylation of benzaldehydes

The applications of a new supported tribromide reagent (poly(vinylbenzyltrimethylammonium tribromide) resin) were reported. This supported tribromide resin was used as a catalyst in the acetalization and diacetylation of benzaldehydes under mild conditions with high efficiency. The effects of solvents, and amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of acetal and 1,1-diacetates of benzaldehydes were selectively obtained in excellent yields.

New Br?nsted-Lewis acidic quaternary ammonium ionic liquids: Synthesis, acidity determination and acidity-catalytic activity relationship

A series of new Br?nsted-Lewis acidic ionic liquids, which are operational simplicity, high stability, low cost and applicable for scaling up, have been synthesized and their activity for acetalization was examined. The comprehensive studies on the acidity-catalytic performance relationship of the Br?nsted-Lewis acidic ionic liquids were performed. IR spectroscopy results confirmed that the new Br?nsted-Lewis acidic ionic liquids possess both Br?nsted and Lewis acid sites. The acidities were determined by Hammett method, and further studies on acidity-activity relationship revealed that the acidity played a key role in the acid-catalyzed probe reactions.

Facile aldolization catalyzed by ionic liquid [4-sulfbmpyrazine][BF 4]

The acidic functionalized ionic liquid 1-(4-sulfonic group)butyl-3- methylpyrazine tetrafluoroborate (abbreviated as [4-sulfbmpyrazine][BF 4]) was employed as the catalyst of the condensation of aromatic aldehyde and diols. The optimized condition was as follows: aromatic aldehyde (0.20 mol), diols (0.30 mol) and [4-sulfbmpyrazine][BF4] (0.60 g) were refluxed in cyclohexane (10.00 mL) for 1 h. A series of aromatic aldehydes were studied and afforded the corresponding acetals products with good yields which were from 70.3 to 96.9 %. The ionic liquid catalyst could be recycled for four times without significant loss of catalyst reactivity.