54596-69-9

Basic information

• Product Name: 2-(HEXYLAMINO)ETHANOL
• Synonyms: 2-(hexylamino)-ethano;Ethanol, 2-(hexylamino)-;2-(HEXYLAMINO)ETHANOL;TIMTEC-BB SBB007879;N-(2-Hydroxyethyl)hexylamine;N-Hexylethanolamine;Einecs 259-251-1
• CAS NO: 54596-69-9
• Molecular Formula: C₈H₁₉NO
• Molecular Weight: 145.24
• EINECS: 259-251-1
• Mol File: 54596-69-9.mol

Chemical Properties

• Boiling Point: 237.9°C at 760 mmHg
• Flash Point: 78.5°C
• Appearance: /
• Density: 0.87g/cm³
• Vapor Pressure: 0.00779mmHg at 25°C
• Refractive Index: 1.442
• PKA: 14.83±0.10(Predicted)
• CAS DataBase Reference: 2-(HEXYLAMINO)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(HEXYLAMINO)ETHANOL(54596-69-9)
• EPA Substance Registry System: 2-(HEXYLAMINO)ETHANOL(54596-69-9)

Safety Data

• Hazardous Substances Data: 54596-69-9(Hazardous Substances Data)

Usage

Uses

Used in Personal Care and Household Products Industry:
2-(HEXYLAMINO)ETHANOL is used as a surfactant and emulsifier for the production of various personal care and household products, such as shampoos, conditioners, and cleaning agents. Its ability to reduce surface tension allows these products to spread more easily and form stable emulsions, enhancing their performance and user experience.
Used in Chemical Synthesis:
2-(HEXYLAMINO)ETHANOL also serves as an intermediate in the synthesis of other chemicals, contributing to the creation of a wide range of compounds used across different industries.
Used in Metalworking Fluids:
Furthermore, 2-(HEXYLAMINO)ETHANOL is utilized as a corrosion inhibitor in metalworking fluids, helping to protect metal surfaces from degradation and prolonging the life of machinery and tools.
However, it is crucial to handle 2-(HEXYLAMINO)ETHANOL with care, as it can cause skin and eye irritation. It should be used in well-ventilated areas to ensure safety during its application in various industries.

InChI:InChI=1/C8H19NO/c1-2-3-4-5-6-9-7-8-10/h9-10H,2-8H2,1H3

Upstream product

• 75-21-8 oxirane 
• 111-26-2 hexan-1-amine 
• 111-25-1 1-bromo-hexane 
• 141-43-5 ethanolamine 
• 111-27-3 hexan-1-ol 

Downstream Products

• 1204408-36-5 2-((2,6-dinitro-4-trifluoromethyl-phenyl)-hexylamino)-ethanol 
• 111541-59-4 N-hexyl-N-(2-p-toluenesulfonyloxyethyl)-5-isoquinolinesulfonamide 
• 346732-41-0 2-[Hexyl(3-Nitrobenzyl)Amino]Ethanol 
• 346732-74-9 2-[Hexyl(2-Methoxy-5-Nitrobenzyl)Amino]Ethanol Hydrochloride 

Relevant articles and documents

Discovery of Axelopran (TD-1211): A Peripherally Restricted μ-Opioid Receptor Antagonist

The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed to a growing opioid epidemic in the United States. Gastrointestinal dysfunction is an additional serious consequence of opioid use, and this can be treated with a localized drug distribution of a non-CNS penetrant, peripherally restricted opioid receptor antagonist. Herein, we describe the application of Theravance's multivalent approach to drug discovery coupled with a physicochemical property design strategy by which the N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenyl carboxamide series of μ-opioid receptor antagonists was optimized to afford the orally absorbed, non-CNS penetrant, Phase 3 ready clinical compound axelopran (TD-1211) 19i as a potential treatment for opioid-induced constipation.

N-Alkylation of Alkylolamines with Alcohols Over Mesoporous Solid Acid–Base Cs–B–Zr Catalyst

Abstract: The mesoporous solid acid–base Cs–B–Zr mixed oxides were synthesized using the co-precipitation method followed by a subsequent thermal treatment. The catalytic activity of solid Cs–B–Zr mixed oxide was tested for solvent free acid–base catalysed direct alkylolamines with alcohols as green alkylating agent. The effects of Cs/B/Zr ratio, calcination temperature, reaction conditions, and reaction substrate on the catalytic performance of the catalysts were investigated. The XRD, N2 adsorption–desorption, ICP-OES, FT-IR and NH3/CO2-TPD results showed that the mesoporous structure and acid–base properties of the catalysts play important roles in the reaction. A suitable number of acid and basic sites on the catalyst lead to a high activity for the N-alkylation reaction. Graphical Abstract: A direct N-alkylation of amino alcohol with alcohols has been developed using mixed oxide Cs–B–Zr as an acid–base bifunctionalized catalyst.[Figure not available: see fulltext.]

Phosphorous amine lubricant additives

Lubricant additives are produced by reacting an alkoxylated amine with phosphorous acid. The additives preferably also contain a boron moiety which is reacted with the phosphorous acid and amine, preferably in a one step reaction. More preferably, a mono-functional alcohol or a long-chain aliphatic carboxylic acid is added to this mixture. The additives are particularly useful in metal working oils and particularly as extreme pressure additives to replace the currently used chlorinated paraffin additives.