54598-44-6Relevant academic research and scientific papers
CYCLOHEXYL SUBSTITUTED TRIAZOLES AS VASOPRESSIN RECEPTOR V1 A ANTAGONISTS
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Page/Page column 63-65, (2022/03/02)
The invention provides novel compounds having the general formula I wherein R1, R2 and R3 are as defined herein, compositions including the compounds and methods of using the compounds.
Imino Carbene Compounds and Derivatives, and Catalyst Compositions Made Therefrom
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, (2012/11/07)
The present invention provides imino carbene compounds and their derivatives, catalyst compositions containing these compounds in combination with an activator, and polymerization processes using these catalyst compositions to polymerize one or more olefi
Formimidoyl Group Transfer from Activated Amidines. Part 1. Hydrolysis of 1-(N-t-Butylformimidoyl)imidazole and Related Imidazole-containing Formamides
Chandler, Anne,Hegarty, Anthony F.,McCormack, Margaret T.
, p. 1318 - 1325 (2007/10/02)
The hydrolysis of 1-(N-t-butylformimidoyl)imidazole (7a) to t-butylformamide and imidazole has been examined in the absence of buffer species at 25 deg C in water.The rate of hydrolysis was pH-independent at pH 7-14 and reaction in this region is shown to occur via HO- attack on the protonated substrate (whose pKa is 5.0; protonation site, imidazole nitrogen).Alternative mechanisms such as H2O attack on the neutral substrate and reaction via the zwitterion (15) were eliminated using solvent isotope effect, deuterium labelling, and substituent effects.Below pH 6 acid catalysis of hydrolysis is observed due to H2O reaction with the protonated substrate (pH 4-6) and with the diprotonated substrate (pH 0-4); at pH 0, t1/2 for hydrolysis is -2s.The N-arylformamidines (7b) and (7c) react via similar acid catalysed pathways but a new reaction (identified as HO- attack on the amidine) occurs in base, in preference to the pH independent pathways. p-Nitrophenylformamide is itself hydrolysed in basic solution so that complex kinetics result.The C-substitued amidines (7e) and (7f) react 104-102-fold more slowly than the corresponding formamidines.Buffer catalysis of the hydrolysis of (7a) by phosphate and amines is complex, the slope of kobs. versus plots being greater at low than at high buffer concentrations.This is consistent with the formation of a tetrahedral intermediate in the reaction pathway whose formation and beakdown is subject to general acid-base catalysis.
