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546-93-0

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546-93-0 Usage

Description

Different sources of media describe the Description of 546-93-0 differently. You can refer to the following data:
1. Magnesium carbonate (MgCO3, pKso=7.5-8.2), another important compound of magnesium, occurs naturally as magnesite,but the magnesium carbonate used in the United States is all synthetically manufactured. It's used in the pharmaceutical industry as an inert material: whenever you take a tablet, chances are, you're also taking magnesium carbonate. Its used as an inert binder to hold the actual particles of the drug together.It's also used in cosmetics, talcum powders, and the manufacture of soap because it can hold and carry a scent very effectively. Magnesium carbonate is added to rubber and plastics as a flame retardant: it reduces the rate at which fire spreads and the amount of char and ash that is produced.
2. Magnesium carbonate is obtained mainly by mining the natural mineral magnesite. The trihydrate salt, MgCO3·3H2O, is prepared by mixing solutions of magnesium and carbonate ions in the presence of carbon dioxide.

Chemical Properties

Different sources of media describe the Chemical Properties of 546-93-0 differently. You can refer to the following data:
1. Magnesium carbonate is a white, yellowish, grayish-white or brown crystalline solid or crystalline powder. It occurs in nature as the mineral magnesite and is an important source of elemental magnesium. It can be produced artificially by the action of carbon dioxide on a variety of magnesium compounds. Magnesium carbonate is a flux. It can be used to make matte, but too much can cause pinholes. Cobalt will produce violet hues when combined with magnesium carbonate, and pink shades when combined with zinc. Magnesium carbonates can be used as magnesium source for the manufacture of catalyst compounds.
2. Magnesium carbonate occurs as light, white-colored friable masses or as a bulky, white-colored powder. It has a slightly earthy taste and is odorless but, since it has a high absorptive ability, magnesium carbonate can absorb odors. The USP 32 describes magnesium carbonate as either a basic hydrated magnesium carbonate or a normal hydrated magnesium carbonate. However, the PhEur describes magnesium carbonate as being a hydrated basic magnesium carbonate in two separate monographs: heavy magnesium carbonate and light magnesium carbonate. The molecular formulas for heavy magnesium carbonate and light magnesium carbonate vary, but heavy magnesium carbonate may generally be regarded as the tetrahydrate [(MgCO3)3·Mg(OH)2·4H2O], while light magnesium carbonate may be regarded as the trihydrate [(MgCO3)3· Mg(OH)2·3H2O]. The molecular weights of the heavy and light forms of magnesium carbonate are 383.32 and 365.30, respectively.

Magnesium Compounds

Compound ? ? ? ? ? ? ? ? Mineral ? ? ? ? ? ? ? ?Formula ? ? ? ? ? ? ? ? ? ? CAS No. anhydrous salt ? ? ? ? ? ? magnesite ? ? ? ? ? ? ?MgCO3 ? ? ? ? ? ? ? ? ? ? ? [13717-00-5] dihydrate ? ? ? ? ? ? ? ?barringtonite ? ? ? ? ? MgCO3?2H2O ? ? ? ? ? ? ? ? ? ?[5145-48-2] trihydrate ? ? ? ? ? ? ??nesquehonite ? ? ? ? ??MgCO3?3H2O ? ? ? ? ? ? ? ? ? ?[14457-83-1] pentahydrate ? ? ? ? ? ? ?lansfordite ? ? ? ? ? ?MgCO3?5H2O ? ? ? ? ? ? ? ? ? ? [61042-72-6] basic carbonate ? ? ? ? ? ?artinite ? ? ? ? ? ? ?MgCO3?Mg(OH)2?3H2O ? ? ? ? ? ? ??[12143-96-3] basic carbonate ? ? ? ? ? ?hydromagnestite ? ? ? ??4MgCO3?Mg(OH)2?4H2O ? ? ? ? [12072-90-1] basic carbonate ? ? ? ? ? ?dypingite ? ? ? ? ? ??4MgCO3?Mg(OH)2?5H2O ? ? ? ? ? ? ? ?[12544-02-4] basic carbonate?? ? ? ? ? ? ?--- ? ? ? ? ? ? ? 4MgCO3?Mg(OH)2?8H2O ? ? ? ? ? ? ? ?[75300-49-1]

Occurrence and Uses

Magnesium carbonate occurs in nature in several minerals as hydrated, basic and double salts, as shown above. The two principal minerals are magnesite, MgCO3 and dolomite, a double salt, CaCO3?MgCO3. Both minerals are used as source materials in the production of magnesium metal. Also, they are calcined to produce basic refractory bricks. Other applications of magnesium carbonate are in flooring, fireproofing and fire-extinguishing compositions; as a filler material and smoke suppressant in plastics; as a reinforcing agent in neoprene rubber; as a drying agent and for color retention in foods; in cos-metics; in dusting powder; and in toothpaste. The high purity magnesium carbonate is used as an antacid in medicine; and as an additive to table salt. Another important application of magnesium carbonate is as a starting material in producing a number of magnesium compounds.

Physical properties

This material is available in a very light, fluffy grade which absorbs well. The before-mentioned qualities are why magnesium carbonate is often used to absorb perfume before incorporation into face powders.

Uses

Different sources of media describe the Uses of 546-93-0 differently. You can refer to the following data:
1. Chemical intermediate for magnesium salts; component of pharmaceuticals, cosmetics, dentifrices, free-running table salt; agent in heat insulation and refractory applications
2. Some applications of magnesiumcarbonate are uses in flooring, fireproofing and fire-extinguishing compositions; as a filler material and smoke suppressant in plastics; as a reinforcing agent in neoprene rubber; as a drying agent and for color retention in foods; in cosmetics. Magnesium carbonate is used as an antacid in medicine and as an additive to table salt. Another important application of magnesium carbonate is as a starting material in producing a number of magnesium compounds. Because of its water-insoluble, hygroscopic properties, MgCO3 was first added to salt in 1911 to make the salt flow more freely. Magnesium carbonate, most often referred to as “chalk”, is used as a drying agent for hands in gymnastics, weight lifting and rock climbing. Magnesium carbonate is also used in taxidermy for whitening skulls. It can be mixed with hydrogen peroxide to create a paste, which is then spread on the skull to give it awhite finish. Basic magnesium carbonate is used as a clay in face masks and it has mild astringent properties and helps to smooth and soften skin. It is recommended for use on normal to dry skins.
3. Used in Pharmaceutical units as a Magnesium Salt, Heat Insulator and Refractor, Antacid. Also used in Cosmetics, inks, glass, drying agent, color retention agent and etc.

Definition

Different sources of media describe the Definition of 546-93-0 differently. You can refer to the following data:
1. The term magnesite is loosely used as a synonym for magnesia as are also the terms caustic-calcined magnesite, dead-burned magnesite, and synthetic magnesite.
2. A whitecompound, MgCO3, existing in anhydrousand hydrated forms. The anhydrousmaterial (trigonal; r.d.2.96) is found in the mineral magnesite.There is also a trihydrate,MgCO3.3H2O (rhombic; r.d. 1.85),which occurs naturally as nesquehonite,and a pentahydrate, MgCO3.5H2O (monoclinic; r.d. 1.73),which occurs as lansfordite. Magnesiumcarbonate also occurs in themixed salt dolomite (CaCO3.MgCO3)and as basic magnesium carbonatein the two minerals artinite(MgCO3.Mg(OH)2.3H2O) and hydromagnesite(3MgCO3.Mg(OH)2.3H2O).The anhydrous salt can be formed byheating magnesium oxide in astream of carbon dioxide:MgO(s) + CO2(g) → MgCO3(s)Above 350°C, the reverse reactionpredominates and the carbonate decomposes.Magnesium carbonate isused in making magnesium oxideand is a drying agent (e.g. in tablesalt). It is also used as a medicalantacid and laxative (the basic carbonateis used) and is a componentof certain inks and glasses.
3. hydromagnesite: A mineral formof basic magnesium carbonate,3MgCO3.Mg(OH)2.3H2O.
4. lansfordite: A mineral form ofmagnesium carbonate pentahydrate,MgCO3.5H2O.

Production Methods

Depending upon the manufacturing process used, the composition of the magnesium carbonate obtained may vary from normal hydrated magnesium carbonate to basic hydrated magnesium carbonate. Light magnesium carbonate may be manufactured by saturating an aqueous suspension of dolomite, CaMg(CO3)2, with carbon dioxide under pressure. On increase of the temperature, calcium carbonate precipitates almost entirely. The filtered solution is then heated to boiling; the magnesium bicarbonate in the solution loses precipitates. Heavy magnesium carbonate may be manufactured by mixing a hot concentrated solution of magnesium chloride or magnesium sulfate with a solution of sodium carbonate. The heavy magnesium carbonate may be either precipitated to produce a granular material or spray-dried. Varying the temperature of the reaction solutions produces heavy magnesium carbonate with differing physical properties: e.g. material with a higher specific surface area is produced at a lower reaction temperature. Low processing temperature provided the largest surface area, which produced optimum granules or spray-dried powder.If dilute magnesium chloride or magnesium sulfate solutions are used for the reaction, a less dense material is produced. Magnesium carbonates in varying states of hydration are also found as minerals in nature.

General Description

White, yellowish, grayish-white or brown crystalline solid or crystalline powder. Density: 3-3.1 g cm-3. An important ore for magnesium. Used in the manufacture of materials capable of withstanding very high temperatures. Sometimes used to produce carbon dioxide.

Reactivity Profile

Magnesium carbonate has generally low chemical reactivity. Non-flammable and non-combustible. Reacts with acids and acidic salts to generate gaseous carbon dioxide with effervescence (bubbling). The reaction may be rapid and exothermic with concentrated solutions of acids. The efferversence can create foaming. Incompatible with formaldehyde.

Hazard

A nuisance particulate.

Health Hazard

Magnesite is considered to be a nuisance dust.

Flammability and Explosibility

Nonflammable

Pharmaceutical Applications

As an excipient, magnesium carbonate is mainly used as a directly compressible tablet diluent in concentrations up to 45% w/w. Heavy magnesium carbonate produces tablets with high crushing strength, low friability, and good disintegration properties. However, magnesium carbonate can have varying effects on dissolution and stability.Magnesium carbonate has been incorporated in microsphere formulations for the purpose of stabilizing encapsulated proteins. It has also been coencapsulated in poly(lactide-co-glycolide) microsphere formulations to neutralize acidity and enhance the immunogenicity of a contraceptive peptide vaccine. Magnesium carbonate is also used to absorb liquids, such as flavors, in tableting processes. Magnesium carbonate is additionally used as a food additive and therapeutically as an antacid.

Agricultural Uses

Different sources of media describe the Agricultural Uses of 546-93-0 differently. You can refer to the following data:
1. Hydromagnesite is a magnesium ore which occurs as a carbonate. Magnesium carbonate occurs in a mixed salt dolomite (CaCO3.MgCO3) and as basic magnesium carbonate in two minerals, namely, artinite (MgCO3.Mg(OH)2.3H2O) and hydromagnesite (3MgCO3.Mg(OH)2.3H2O).
2. Magnesium carbonate is a white compound occurring in anhydrous and hydrated forms. It is used as a fertilizer and also for making magnesium oxide. The anhydrous material is found naturally in mineral magnesite. There is also a trihydrate, MgC03·3H2O (rhombic) that occurs naturally as nesquehonite, and a pentahydrate, MgCO3.5H2O (monoclinic) that occurs as lansfordite. Magnesium carbonate also occurs in a mixed salt dolomite (CaCO3·MgCO3) and as basic magnesium carbonate in two minerals, namely, artinite [MgCO3·Mg(OH)2.3H2O] and hydromagnesite [3MgC03·Mg(OH)2.3H2O]. Heating magnesium oxide in a stream of carbon dioxide leads to the formation of the anhydrous salt. Above 350°C, the reverse reaction predominates and the carbonate decomposes to give back MgO.
3. Nesquehonite is the natural form of magnesium carbonate trihydrate (MgCO3.3H2O).

Safety

Magnesium carbonate is used as an excipient in oral solid-dosage pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. However, the use of magnesium salts, such as magnesium carbonate, is contraindicated in patients with renal impairment. In certain studies, magnesium carbonate has been shown to be an effective phosphate binder in short-term use for patients with chronic kidney disease, but the effects of long-term use require further study.The probable oral lethal dose in humans has been estimated at 0.5–5.0g/kg bodyweight. On contact with gastric acid, magnesium carbonate reacts in the stomach to form soluble magnesium chloride and carbon dioxide. Magnesium carbonate should therefore not be used as an antacid by those individuals whose stomachs cannot tolerate the evolution of carbon dioxide. Some magnesium is absorbed but is usually excreted in the urine. As with other magnesium salts, magnesium carbonate has a laxative effect and may cause diarrhea. Therapeutically, the usual dose of magnesium carbonate as an antacid is 250–500mg, and 2.0–5.0g as a laxative.

storage

Magnesium carbonate is stable in dry air and on exposure to light. The bulk material should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Incompatible with phenobarbital sodium,diazepam solution at a pH≥5, some binary powder mixtures, lansoprazole, and formaldehyde. Acids will dissolve magnesium carbonate, with the liberation of carbon dioxide. Slight alkalinity is imparted to water. Magnesium carbonate was also found to increase the dissolution of acetazolamide formulations at a pH of 1.12; however, dissolution was retarded at a pH of 7.4.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK.

Check Digit Verification of cas no

The CAS Registry Mumber 546-93-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 546-93:
(5*5)+(4*4)+(3*6)+(2*9)+(1*3)=80
80 % 10 = 0
So 546-93-0 is a valid CAS Registry Number.
InChI:InChI=1/CH2O3.Mg/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

546-93-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name magnesium carbonate

1.2 Other means of identification

Product number -
Other names Carbonic acid,magnesium salt (1:1)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Processing Aids and Additives
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:546-93-0 SDS

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