54605-99-1

Basic information

• Product Name: (4-methoxyphenyl)(3-methyl-4,5-dihydroioxazol-5-yl)methanone
• CAS NO: 54605-99-1
• Molecular Weight: 219.24
• Mol File: 54605-99-1.mol

Chemical Properties

• CAS DataBase Reference: (4-methoxyphenyl)(3-methyl-4,5-dihydroioxazol-5-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methoxyphenyl)(3-methyl-4,5-dihydroioxazol-5-yl)methanone(54605-99-1)
• EPA Substance Registry System: (4-methoxyphenyl)(3-methyl-4,5-dihydroioxazol-5-yl)methanone(54605-99-1)

Safety Data

• Hazardous Substances Data: 54605-99-1(Hazardous Substances Data)

Upstream product

• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 7063-95-8 acetonitrile-N-oxide 
• 34419-97-1 (2-(4-methoxyphenyl)-2-oxoethyl)dimethylsulfonium bromide 
• 102588-22-7 N,N-bis(trimethylsilyloxy)-1-propen-2-amine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Synthesis of Isoxazolines from Nitroalkanes via a [4+1]-Annulation Strategy

A novel access to isoxazolines was developed using the [4+1]-annulation of α-keto-stabilized sulfur ylides with N,N-bis(siloxy)enamines derived from aliphatic nitro compounds. The resulting 5-keto-substituted isoxazolines were shown to be convenient precursors of polysubstituted 3-hydroxypyrrolidines via the one-pot catalytic N?O hydrogenolysis/intramolecular reductive amination sequence. Application of this approach to the formal synthesis of Merck's potent NK1 receptor antagonist was demonstrated. (Figure presented.).