54606-03-0

Basic information

• Product Name: trans-(4-methyl-3-phenyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone
• CAS NO: 54606-03-0
• Molecular Weight: 265.312
• Mol File: 54606-03-0.mol

Chemical Properties

• CAS DataBase Reference: trans-(4-methyl-3-phenyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: trans-(4-methyl-3-phenyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone(54606-03-0)
• EPA Substance Registry System: trans-(4-methyl-3-phenyl-4,5-dihydroisoxazol-5-yl)(phenyl)methanone(54606-03-0)

Safety Data

• Hazardous Substances Data: 54606-03-0(Hazardous Substances Data)

Upstream product

• 5279-14-1 1-phenyl-1-nitropropane 
• 2157-50-8 propiophenone oxime 

Relevant articles and documents

Synthesis of Isoxazolines from Nitroalkanes via a [4+1]-Annulation Strategy

A novel access to isoxazolines was developed using the [4+1]-annulation of α-keto-stabilized sulfur ylides with N,N-bis(siloxy)enamines derived from aliphatic nitro compounds. The resulting 5-keto-substituted isoxazolines were shown to be convenient precursors of polysubstituted 3-hydroxypyrrolidines via the one-pot catalytic N?O hydrogenolysis/intramolecular reductive amination sequence. Application of this approach to the formal synthesis of Merck's potent NK1 receptor antagonist was demonstrated. (Figure presented.).