546078-34-6Relevant articles and documents
Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues
Cheng, Qian,Kiyota, Hiromasa,Yamaguchi, Marina,Horiguchi, Tohru,Oritani, Takayuki
, p. 1075 - 1077 (2007/10/03)
Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.