54610-75-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Thiophenecarboxamidine is used as a potential anti-tumor agent for its ability to inhibit the growth of cancer cells. It has shown promising results in preclinical studies, making it a candidate for further research and development in cancer treatment.
2-Thiophenecarboxamidine is also used as a potential anti-diabetic agent, as it has been investigated for its role in the treatment of diabetes. Its potential to modulate glucose metabolism and improve insulin sensitivity makes it a candidate for further exploration in diabetes management.
Additionally, 2-Thiophenecarboxamidine is used as a potential anti-inflammatory agent, given its investigation for its role in treating inflammatory conditions. Its ability to modulate inflammatory pathways and reduce inflammation may contribute to the development of new therapeutic approaches for various inflammatory disorders.

InChI:InChI=1/C5H6N2S/c6-5(7)4-2-1-3-8-4/h1-3H,(H3,6,7)

Upstream product

• 1003-31-2 thiophene-2-carbonitrile 

Downstream Products

• 87568-78-3 4-Methylsulfanyl-6-phenyl-2-thiophen-2-yl-pyrimidine 
• 102152-10-3 5-(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 
• 59918-60-4 3,6-di(thiophen-2-yl)-1,2,4,5-tetrazine 
• 212621-73-3 5-(5-methyl-[1,3,4]oxadiazol-2-yl)-4-phenylmethanesulfonyl-2-thiophen-2-yl-pyrimidine 
• 212621-53-9 4-benzylsulfanyl-2-thiophen-2-yl-pyrimidine-5-carboxylic acid (2-hydroxy-ethyl)-amide 
• 212621-72-2 5-(2-methyl-2H-tetrazol-5-yl)-4-phenylmethanesulfonyl-2-thiophen-2-yl-pyrimidine 
• 212621-58-4 4-benzylsulfanyl-5-(5-methyl-[1,3,4]oxadiazol-2-yl)-2-thiophen-2-yl-pyrimidine 
• 212621-46-0 4-benzylsulfanyl-5-(2-methyl-2H-tetrazol-5-yl)-2-thiophen-2-yl-pyrimidine 
• 212621-42-6 4-benzylsulfanyl-5-(3-methyl-isoxazol-5-yl)-2-thiophen-2-yl-pyrimidine 

Relevant academic research and scientific papers

1,2,4,6-Thiatriazinyl radicals and dimers: Structural and electronic tuning through heteroaromatic substituent modification

The functionalization of thiatriazinyl (TTA) radicals with pyridyl and thienyl moieties is described, and their influence at both the molecular and solid-state level has been investigated. Comparative electron paramagnetic resonance studies of 3,5-bis-(2-pyridyl)-1,2,4,6-thiatriazinyl (Py2TTA) and 3,5-bis-(2-thienyl)-1,2,4,6-thiatriazinyl (Th2TTA) reveal the impact of heteroaromatic substitution on the electronic structure, which is supported by density functional theory calculations. Single crystal X-ray analysis emphasizes the importance of intermolecular contacts on the crystal packing and demonstrates the potential for structural control through S - -N′ and N - -HC′ interactions, which are enhanced in Py2TTA and Th2TTA by the presence of the pyridyl and thienyl groups, respectively. This work represents a fundamental study of heterocyclic aromatic substitution in thiazyl-based radicals and investigates how varying these functional groups influences the molecular properties and long-range order within the supramolecular structure.

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

Synthesis of ultrahighly electron-deficient pyrrolo[3,4- d ]pyridazine-5,7-dione by inverse electron demand diels-alder reaction and its application as electrochromic materials

A new electron acceptor 6-alkylpyrrolo[3,4-d]pyridazine-5,7-dione (PPD) with a very low LUMO level has been synthesized via a challenging inverse electron demand Diels-Alder reaction between thiophene and furan-decorated tetrazine substrates and an electron-deficient 1-alkyl-1H-pyrrole-2,5-dione unit. The PPD monomer has been incorporated into a series of donor-acceptor-type conjugated polymers as electrochromic materials with good optical contrast, fast switching speed, and high coloration efficiency.

METHOD OF TREATING CONDITIONS SUSCEPTIBLE TO MODULATION OF NPY RECEPTORS WITH DIARYLIMIDAZOLE DERIVATIVES

Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. Many of the compounds are novel.