54610-75-2

Basic information

• Product Name: 2-THIOPHENECARBOXAMIDINE
• Synonyms: 2-Thiophenecarboximidamide;2-Thiophenecarboximidamide(9CI);THIOPHENE-2-CARBOXAMIDINE
• CAS NO: 54610-75-2
• Molecular Formula: C₅H₆N₂S
• Molecular Weight: 126.17954
• Product Categories: AMIDINE
• Mol File: 54610-75-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 220.8°C at 760 mmHg
• Flash Point: 87.3°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 0.111mmHg at 25°C
• Refractive Index: 1.675
• PKA: 11.70±0.40(Predicted)
• CAS DataBase Reference: 2-THIOPHENECARBOXAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIOPHENECARBOXAMIDINE(54610-75-2)
• EPA Substance Registry System: 2-THIOPHENECARBOXAMIDINE(54610-75-2)

Safety Data

• Hazardous Substances Data: 54610-75-2(Hazardous Substances Data)

Usage

General Description

2-Thiophenecarboxamidine is a compound with the chemical formula C5H6N2S. It is a member of the amidine family of compounds, which are known for their diverse biological activities. 2-Thiophenecarboxamidine has been studied for its potential anti-tumor, anti-diabetic, and anti-inflammatory properties. It has shown promising results in inhibiting the growth of cancer cells in preclinical studies. Additionally, it has been investigated for its role in the treatment of diabetes and inflammatory conditions. Overall, 2-Thiophenecarboxamidine is a compound of interest in the field of medicinal chemistry due to its potential therapeutic applications.

InChI:InChI=1/C5H6N2S/c6-5(7)4-2-1-3-8-4/h1-3H,(H3,6,7)

Upstream product

• 1003-31-2 thiophene-2-carbonitrile 

Downstream Products

• 87568-78-3 4-Methylsulfanyl-6-phenyl-2-thiophen-2-yl-pyrimidine 
• 102152-10-3 5-(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 
• 59918-60-4 3,6-di(thiophen-2-yl)-1,2,4,5-tetrazine 
• 212621-73-3 5-(5-methyl-[1,3,4]oxadiazol-2-yl)-4-phenylmethanesulfonyl-2-thiophen-2-yl-pyrimidine 
• 212621-53-9 4-benzylsulfanyl-2-thiophen-2-yl-pyrimidine-5-carboxylic acid (2-hydroxy-ethyl)-amide 
• 212621-72-2 5-(2-methyl-2H-tetrazol-5-yl)-4-phenylmethanesulfonyl-2-thiophen-2-yl-pyrimidine 
• 212621-58-4 4-benzylsulfanyl-5-(5-methyl-[1,3,4]oxadiazol-2-yl)-2-thiophen-2-yl-pyrimidine 
• 212621-46-0 4-benzylsulfanyl-5-(2-methyl-2H-tetrazol-5-yl)-2-thiophen-2-yl-pyrimidine 
• 212621-42-6 4-benzylsulfanyl-5-(3-methyl-isoxazol-5-yl)-2-thiophen-2-yl-pyrimidine 
• 212621-49-3 4-benzylsulfanyl-5-(4-methyl-oxazol-2-yl)-2-thiophen-2-yl-pyrimidine 

Relevant articles and documents

1,2,4,6-Thiatriazinyl radicals and dimers: Structural and electronic tuning through heteroaromatic substituent modification

The functionalization of thiatriazinyl (TTA) radicals with pyridyl and thienyl moieties is described, and their influence at both the molecular and solid-state level has been investigated. Comparative electron paramagnetic resonance studies of 3,5-bis-(2-pyridyl)-1,2,4,6-thiatriazinyl (Py2TTA) and 3,5-bis-(2-thienyl)-1,2,4,6-thiatriazinyl (Th2TTA) reveal the impact of heteroaromatic substitution on the electronic structure, which is supported by density functional theory calculations. Single crystal X-ray analysis emphasizes the importance of intermolecular contacts on the crystal packing and demonstrates the potential for structural control through S - -N′ and N - -HC′ interactions, which are enhanced in Py2TTA and Th2TTA by the presence of the pyridyl and thienyl groups, respectively. This work represents a fundamental study of heterocyclic aromatic substitution in thiazyl-based radicals and investigates how varying these functional groups influences the molecular properties and long-range order within the supramolecular structure.

Synthesis of ultrahighly electron-deficient pyrrolo[3,4- d ]pyridazine-5,7-dione by inverse electron demand diels-alder reaction and its application as electrochromic materials

A new electron acceptor 6-alkylpyrrolo[3,4-d]pyridazine-5,7-dione (PPD) with a very low LUMO level has been synthesized via a challenging inverse electron demand Diels-Alder reaction between thiophene and furan-decorated tetrazine substrates and an electron-deficient 1-alkyl-1H-pyrrole-2,5-dione unit. The PPD monomer has been incorporated into a series of donor-acceptor-type conjugated polymers as electrochromic materials with good optical contrast, fast switching speed, and high coloration efficiency.