546113-19-3

Upstream product

• 951307-30-5 1-(p-methoxybenzyl)-4-(p-hydroxybenzyl)imidazole 
• 74-88-4 methyl iodide 
• 3694-57-3 1-(isothiocyanatomethyl)-4-methoxybenzene 
• 2393-23-9 4-methoxy-benzylamine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 546113-15-9 5-{(1-hydroxy)-[1-(4-methoxyphenyl)methyl]}-2-phenylthio-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole 
• 546113-16-0 5-(4-methoxybenzyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-phenylthio-1H-imidazole 
• 546113-17-1 5-(4-methoxybenzyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole 
• 2746-25-0 p-Methoxybenzyl bromide 
• 951307-29-2 1-(p-methoxybenzyl)-4-(p-hydroxybenzyl)imidazole-2-thione 

Downstream Products

• 110189-02-1 4-[2-amino-1-(4-hydroxybenzyl)-1H-imidazol-4-ylmethyl]phenol 
• 110189-04-3 isonaamidine-A 
• 546113-22-8 1,4-bis-(4-methoxybenzyl)-1H-imidazol-2-ylamine 
• 546113-20-6 2-bromo-1,4-bis(4-methoxybenzyl)-1H-imidazole 

Relevant academic research and scientific papers

Facile conversion of amino acids into 1-alkyl imidazole-2-thiones, and their oxidative desulfurization to imidazoles with benzoyl peroxide

Glycine was acylated with isothiocyanates and condensed to 3-alkyl 2-thiohydantoins, which were reduced with a mixture of sodium borohydride and lithium chloride and dehydrated to 1-alkyl imidazole-2-thiones. These were oxidatively desulfurized to imidazoles with benzoyl peroxide. No chromatography was required for model compounds. The methods developed were used to elaborate tyrosine to 1,4-di(p-methoxybenzyl)imidazole, a common intermediate in the syntheses of three imidazoles from the sponge Leucetta. Georg Thieme Verlag Stuttgart.

1-Methyl-3-trimethylsilylparabanic acid as an effective reagent for the preparation of N-substituted (1-methyl-2,5-dioxo-1,2,5H-imidazolin-4-YL)-amines and its application to the total synthesis of isonaamidines A and C, antitumor imidazole alkaloids

1-Methyl-3-trimethylsilylparabanic acid (17) was successfully used in the final step of the total synthesis of isonaamidine A (9), isonaamidine C (11) and pyronaamidine (8), antitumor marine imidazole alkaloids.