546113-68-2

Upstream product

• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 546113-65-9 C₃₃H₃₀N₃O₁₀P 
• 302346-91-4 3-propenyl-(2',3'-O,N⁴-tribenzoyl cytidine-5')-yl-N,N'-diisopropylphosphoramidite 

Relevant academic research and scientific papers

Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases.

Several phosphoramidate analogues of CMP-N-acetylneuraminic acid were prepared for evaluation as inhibitors of alpha-2,3- and alpha-2,6-sialyltransferase. Central to the synthesis was the oxidative coupling of an amino acid ester with an H-phosphonate to construct the phosphoramidate linkage. All compounds synthesized were weak inhibitors of both of the sialyltransferases as determined by an HPLC-based inhibition assay.