5462-04-4Relevant academic research and scientific papers
Dynamic kinetic asymmetric ring-opening/reductive amination sequence of racemic nitroepoxides with chiral amines: Enantioselective synthesis of chiral vicinal diamines
Agut, Juan,Vidal, Andreu,Rodríguez, Santiago,González, Florenci V.
, p. 5717 - 5722 (2013/07/25)
We report a highly diastereoselective synthesis of vicinal diamines by the treatment of nitroepoxides with primary amines and then a reducing agent. When using a chiral primary amine, racemic nitroepoxides are transformed into chiral diamines as a single enantiomers (>95:5 er) through a dynamic kinetic asymmetric transformation (DYKAT). The overall process is a one-pot procedure combining the exposure of nitroepoxides to chiral amines to afford diastereomeric mixtures of aminoimines and subsequent stereoselective imine reduction.
Facile regiocontrolled synthesis of trialkyl-substituted pyrazines
Elmaaty, Tarek Abou,Castle, Lyle W.
, p. 5529 - 5530 (2007/10/03)
(Chemical Equation Presented) α-Nitro ketones can be transformed selectively into trialkyl-substituted pyrazines via reaction with α-amino ketones using octyl viologen as an electron-transfer reagent. The new synthetic method, and the optimal reaction conditions that allow for the regiochemical control, are described.
Method of producing organic compounds in presence of oxyethylene ether catalyst and in a solvent minimized environment
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Page 8-9, (2008/06/13)
A process of producing organic compounds, such as acetaminophen, nitroalcohols and indoles, employs a catalyst system of an oxyethylene ether and a metal containing inorganic or organic reagent. The oxyethylene ether at least partially complexes the metal of the inorganic or organic reagent. As such, the reactions may be conducted neat. The processes are environmentally friendly and operationally simple.
Use of heterogeneous catalyst KG-60-NEt2 in Michael and Henry reactions involving nitroalkanes
Ballini, Roberto,Bosica, Giovanna,Livi, Damiana,Palmieri, Alessandro,Maggi, Raimondo,Sartori, Giovanni
, p. 2271 - 2273 (2007/10/03)
The N,N-diethylpropylamine supported on amorphous silica (KG-60-NEt2) catalyses the formation of carbon-carbon bonds by nitroalkanes through both the nitroaldol (Henry) and Michael reactions. The catalyst shows general utility with a variety of electrophilic acceptors. Moreover, the catalyst can be reused for two further cycles without loss of the activity.
