5463-27-4Relevant academic research and scientific papers
Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis
Wilke, Diego Veras,Jimenez, Paula Christine,Araújo, Renata Mendona,Da Silva, Wildson Max Barbosa,Pessoa, Otília Deusdênia Loiola,Silveira, Edilberto Rocha,Pessoa, Claudia,De Moraes, Manoel Odorico,Skwarczynski, Mariusz,Simerska, Pavla,Toth, Istvan,Costa-Lotufo, Letícia Veras
scheme or table, p. 7997 - 8004 (2011/02/23)
Lipidic α-amino acids (LAAs) have been described as non-natural amino acids with long saturated or unsaturated aliphatic chains. In the continuing prospect to discover anticancer agents from marine sources, we have obtained a mixture of two cytotoxic LAAs (1a and 1b) from the zoanthid Protopalythoa variabilis. The anti-proliferative potential of 14 synthetic LAAs and 1a/1b were evaluated on four tumor cell lines (HCT-8, SF-295, MDA-MB-435, and HL-60). Five of the synthetic LAAs showed high percentage of tumor cell inhibition, while 1a/1b completely inhibited tumor cell growth. Additionally, apoptotic effects of 1a/1b were studied on HL-60 cell line. 1a/1b-treated cells showed apoptosis morphology, loss of mitochondrial potential, and DNA fragmentation.
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase
Kim, In-Hae,Nishi, Kosuke,Tsai, Hsing-Ju,Bradford, Tanya,Koda, Yasuko,Watanabe, Takaho,Morisseau, Christophe,Blanchfield, Joanne,Toth, Istvan,Hammock, Bruce D.
, p. 312 - 323 (2008/02/04)
The soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in blood pressure regulation and vascular inflammation. 12-(3-Adamantan-1-yl-ureido)-dodecanoic acid (AUDA, 1) is a very active inhibit
