54636-34-9Relevant academic research and scientific papers
Chiral isoxazolidine-mediated stereoselective umpolung α-phenylation of methyl ketones
Takeda, Norihiko,Furuishi, Mizuki,Nishijima, Yuri,Futaki, Erika,Ueda, Masafumi,Shinada, Tetsuro,Miyata, Okiko
, p. 8940 - 8943 (2018)
An effective asymmetric α-phenylation of methyl ketones with triphenylaluminium in the presence of (+)-benzopyranoisoxazolidine has been developed. The reaction proceeds via the in situ formation of a chiral N-alkoxyenamine and the subsequent diastereoselective nucleophilic phenylation to provide α-phenylated products in moderate to good yields, with high enantioselectivities.
