5464-48-2Relevant academic research and scientific papers
Straightforward synthesis of optically pure methyl (S)-2-phthalimido-4-oxobutanoate and some of its acetal and thioacetal derivatives
Meffre,Durand,Le Goffic
, p. 1111 - 1114 (2007/10/02)
An improved procedure for the synthesis of optically pure methyl (S)-2-phthalimido-4-oxobutanoate (3a) and some of its acetal and thioacetal derivatives 4, 5 and 7 from cheap commercially available L-methionine methyl ester hydrochloride (1a) is described.
A new simple route to N,O-protected (S)-2-amino-4-oxobutyric acid
Dehmlow,Westerheide
, p. 1225 - 1226 (2007/10/02)
Methionine is converted into the N,O-protected derivative 1b. Chlorination of 1b with sulfuryl chloride results in a mixture of the α-halosulfides 2a and 2b in the ratio of 6:1. Hydrolysis of 2a gives the title compound 3 in 64% yield.
