54647-77-7

Basic information

• Product Name: CBZ-L-VALINE DCHA
• Synonyms: N-CARBOBENZOXY-L-VALINE DICYCLOHEXYLAMMONIUM SALT;CBZ-L-VALINE DCHA;N-[(benzyloxy)carbonyl]-L-valine, compound with dicyclohexylamine (1:1)
• CAS NO: 54647-77-7
• Molecular Formula: C₁₂H₂₃N*C₁₃H₁₇NO₄
• Molecular Weight: 432.6
• EINECS: 259-274-7
• Mol File: 54647-77-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 432.6°C at 760 mmHg
• Flash Point: 215.4°C
• Appearance: /
• Vapor Pressure: 2.99E-08mmHg at 25°C
• CAS DataBase Reference: CBZ-L-VALINE DCHA(CAS DataBase Reference)
• NIST Chemistry Reference: CBZ-L-VALINE DCHA(54647-77-7)
• EPA Substance Registry System: CBZ-L-VALINE DCHA(54647-77-7)

Safety Data

• Hazardous Substances Data: 54647-77-7(Hazardous Substances Data)

Usage

General Description

CBZ-L-valine DCHA is a chemical compound that is derived from valine, an essential amino acid. It is used in the pharmaceutical industry as a building block for the synthesis of peptides and proteins. CBZ-L-VALINE DCHA is often used as a protecting group for the amino acid side chains during peptide synthesis, which helps to control the specificity and selectivity of the reactions. CBZ-L-valine DCHA is also utilized in the preparation of various pharmaceuticals and biologically active molecules due to its ability to serve as a chiral auxiliary. Overall, this compound plays a crucial role in the development and production of diverse pharmaceutical products.

InChI:InChI=1/C13H17NO4.C12H23N/c1-9(2)11(12(15)16)14-13(17)18-8-10-6-4-3-5-7-10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h3-7,9,11H,8H2,1-2H3,(H,14,17)(H,15,16);11-13H,1-10H2

Upstream product

• 72-18-4 L-valine 
• 501-53-1 benzyl chloroformate 
• 101-83-7 N-cyclohexyl-cyclohexanamine 

Downstream Products

• 130633-38-4 Z-Val-Met-OMe 
• 130633-42-0 Z-Val-Met-OEt 
• 54769-26-5 Z-Val-Val-OEt 
• 4817-95-2 N-(benzyloxycarbonyl)-L-valyl-L-phenylalanine methyl ester 
• 20790-63-0 Z-Val-Pro-OEt 
• 51827-14-6 N-[(Phenylmethoxy)carbonyl]-L-valyl-L-proline methyl ester 
• 4817-93-0 (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-4-methylpentanoate 
• 1999-88-8 methyl (S)-2-((S)-2-benzyloxycarbonyl-amino-3-methylbutyrylamino)-3-methylbutyrate 
• 55739-16-7 Z-L-Val-L-Ala-OEt 
• 2766-17-8 ethyl N-(benzyloxycarbonyl)-L-valylglycinate 
• 22221-83-6 benzyloxycarbonyl-L-valyl-L-alanine methyl ester 
• 2421-61-6 N-benzyloxycarbonylvalylglycine methyl ester 
• 686-43-1 valylglycine 

Relevant articles and documents

KINETICS OF THE ALKALINE HYDROLYSIS OF SEVERAL N-BENZYLOXYCARBONYLDIPEPTIDE METHYL AND ETHYL ESTERS

The reaction rates of the alkaline hydrolysis of synthesized N-protected dipeptide methyl and ethyl esters were studied systematically.From the kinetic data the energies of activation, the pre-exponential factors and the reference values at 40 deg C were calculated.The rate of hydrolysis shows to be strongly dependent on the C-terminal amino acid in the sequence Gly >> Ala/Met/Phe > Leu >> Val/Pro.Surprisingly the N-terminal amino acid also exerts an effect, but in a different sequence.N-Terminal Phe in particular shows a relative accelerating effect.Remarkable is the significantly faster ester hydrolysis of glycine containing dipeptide ethyl esters in ethanol/water compared to the corresponding methyl esters in methanol/water.